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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Cash flows from operating activities:      
Net loss $ (742,745)us-gaap_ProfitLoss $ (687,550)us-gaap_ProfitLoss $ (51,135)us-gaap_ProfitLoss
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:      
Depreciation and amortization expense 63,257us-gaap_DepreciationDepletionAndAmortization 48,365us-gaap_DepreciationDepletionAndAmortization 38,191us-gaap_DepreciationDepletionAndAmortization
Stock-based compensation expense 177,542us-gaap_ShareBasedCompensation 127,303us-gaap_ShareBasedCompensation 114,285us-gaap_ShareBasedCompensation
Other non-cash based compensation expense 0us-gaap_OtherNoncashExpense 5,860us-gaap_OtherNoncashExpense 10,261us-gaap_OtherNoncashExpense
Intangible asset impairment charges 0vrtx_ImpairmentofIntangibleAssetsIndefinitelivedExcludingGoodwillIncludingEffectofDiscontinuedOperations 663,500vrtx_ImpairmentofIntangibleAssetsIndefinitelivedExcludingGoodwillIncludingEffectofDiscontinuedOperations 0vrtx_ImpairmentofIntangibleAssetsIndefinitelivedExcludingGoodwillIncludingEffectofDiscontinuedOperations
Deferred income taxes 281us-gaap_IncreaseDecreaseInOtherDeferredLiability (285,053)us-gaap_IncreaseDecreaseInOtherDeferredLiability 36,660us-gaap_IncreaseDecreaseInOtherDeferredLiability
Impairment of property and equipment 1,689us-gaap_AssetImpairmentCharges 7,594us-gaap_AssetImpairmentCharges 0us-gaap_AssetImpairmentCharges
Deconsolidation of variable interest entity 0us-gaap_GainLossOnSaleOfInvestments 55,110us-gaap_GainLossOnSaleOfInvestments 0us-gaap_GainLossOnSaleOfInvestments
Write-downs of inventories to net realizable value 0us-gaap_InventoryWriteDown 10,358us-gaap_InventoryWriteDown 133,189us-gaap_InventoryWriteDown
Excess tax benefit from share-based payment arrangements (2,160)us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities 1,252us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities (1,971)us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities
Other non-cash items, net 0us-gaap_OtherNoncashIncomeExpense 6,742us-gaap_OtherNoncashIncomeExpense 178us-gaap_OtherNoncashIncomeExpense
Changes in operating assets and liabilities, excluding the effects of the acquisition and deconsolidation of variable interest entities:      
Accounts receivable, net 7,428us-gaap_IncreaseDecreaseInAccountsReceivable 53,363us-gaap_IncreaseDecreaseInAccountsReceivable 39,912us-gaap_IncreaseDecreaseInAccountsReceivable
Inventories (16,469)us-gaap_IncreaseDecreaseInInventories 7,142us-gaap_IncreaseDecreaseInInventories (29,925)us-gaap_IncreaseDecreaseInInventories
Prepaid expenses and other assets (15,771)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (12,061)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (23,619)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
Accounts payable 25,048us-gaap_IncreaseDecreaseInAccountsPayable (49,234)us-gaap_IncreaseDecreaseInAccountsPayable 14,892us-gaap_IncreaseDecreaseInAccountsPayable
Accrued expenses and other liabilities (3,270)us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities 43,725us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities 29,232us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities
Accrued restructuring expense 17,502us-gaap_RestructuringReservePeriodIncreaseDecrease 5,025us-gaap_RestructuringReservePeriodIncreaseDecrease (2,985)us-gaap_RestructuringReservePeriodIncreaseDecrease
Deferred revenues (25,531)us-gaap_IncreaseDecreaseInDeferredRevenue (53,011)us-gaap_IncreaseDecreaseInDeferredRevenue (39,324)us-gaap_IncreaseDecreaseInDeferredRevenue
Net cash (used in) provided by operating activities (513,199)us-gaap_NetCashProvidedByUsedInOperatingActivities (51,570)us-gaap_NetCashProvidedByUsedInOperatingActivities 267,841us-gaap_NetCashProvidedByUsedInOperatingActivities
Cash flows from investing activities:      
Purchases of marketable securities (1,424,172)us-gaap_PaymentsToAcquireAvailableForSaleSecurities (2,412,418)us-gaap_PaymentsToAcquireAvailableForSaleSecurities (1,705,829)us-gaap_PaymentsToAcquireAvailableForSaleSecurities
Sales and maturities of marketable securities 1,557,938us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities 2,348,295us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities 1,367,927us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
Payment for acquisition of variable interest entity (10,000)us-gaap_PaymentsToAcquireIntangibleAssets 0us-gaap_PaymentsToAcquireIntangibleAssets 0us-gaap_PaymentsToAcquireIntangibleAssets
Expenditures for property and equipment (51,201)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (51,393)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (71,140)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Decrease in restricted cash and cash equivalents 0us-gaap_IncreaseDecreaseInRestrictedCash 31,804us-gaap_IncreaseDecreaseInRestrictedCash 2,156us-gaap_IncreaseDecreaseInRestrictedCash
Decrease (increase) in restricted cash and cash equivalents (VIE) 1,638us-gaap_IncreaseDecreaseInRestrictedCashAndInvestments 27,884us-gaap_IncreaseDecreaseInRestrictedCashAndInvestments (18,105)us-gaap_IncreaseDecreaseInRestrictedCashAndInvestments
(Increase) decrease in other assets (244)us-gaap_PaymentsForProceedsFromOtherInvestingActivities 1,698us-gaap_PaymentsForProceedsFromOtherInvestingActivities (826)us-gaap_PaymentsForProceedsFromOtherInvestingActivities
Net cash provided by (used in) investing activities 73,959us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (54,130)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (425,817)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities:      
Excess tax benefit from share-based payment arrangements 2,160us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities (1,252)us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities 1,971us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities
Issuances of common stock under benefit plans 274,615us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions 265,878us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions 191,721us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
Payments to redeem secured notes 0us-gaap_RepaymentsOfDebt (158)us-gaap_RepaymentsOfDebt 0us-gaap_RepaymentsOfDebt
Payments on capital lease obligations (21,443)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations (16,057)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations (2,615)us-gaap_RepaymentsOfLongTermCapitalLeaseObligations
Payments on construction financing lease obligation (60,249)us-gaap_ProceedsFromPaymentsForOtherFinancingActivities (67,527)us-gaap_ProceedsFromPaymentsForOtherFinancingActivities (18,873)us-gaap_ProceedsFromPaymentsForOtherFinancingActivities
Proceeds from senior secured term loan 294,243us-gaap_ProceedsFromRepaymentsOfSecuredDebt 0us-gaap_ProceedsFromRepaymentsOfSecuredDebt 0us-gaap_ProceedsFromRepaymentsOfSecuredDebt
Payments returned related to construction financing lease obligation 8,050us-gaap_PaymentsOfFinancingCosts 0us-gaap_PaymentsOfFinancingCosts 0us-gaap_PaymentsOfFinancingCosts
Net cash provided by financing activities 497,376us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 180,884us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 172,204us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Effect of changes in exchange rates on cash (2,176)us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations 4,708us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations (141)us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations
Net increase in cash and cash equivalents 55,960us-gaap_NetCashProvidedByUsedInContinuingOperations 79,892us-gaap_NetCashProvidedByUsedInContinuingOperations 14,087us-gaap_NetCashProvidedByUsedInContinuingOperations
Cash and cash equivalents—beginning of period 569,299us-gaap_CashAndCashEquivalentsAtCarryingValue 489,407us-gaap_CashAndCashEquivalentsAtCarryingValue 475,320us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents—end of period 625,259us-gaap_CashAndCashEquivalentsAtCarryingValue 569,299us-gaap_CashAndCashEquivalentsAtCarryingValue 489,407us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash flow information:      
Cash paid for interest 8,714us-gaap_InterestPaid 11,015us-gaap_InterestPaid 13,400us-gaap_InterestPaid
Cash paid for income taxes 1,210us-gaap_IncomeTaxesPaidNet 2,840us-gaap_IncomeTaxesPaidNet 9,318us-gaap_IncomeTaxesPaidNet
Conversion of convertible senior subordinated notes (due 2015) for common stock 0vrtx_DebtConversionOrExchangeConvertedOrExchangedInstrumentAmount 399,842vrtx_DebtConversionOrExchangeConvertedOrExchangedInstrumentAmount 0vrtx_DebtConversionOrExchangeConvertedOrExchangedInstrumentAmount
Unamortized deferred debt issuance costs exchanged 0us-gaap_WriteOffOfDeferredDebtIssuanceCost 4,230us-gaap_WriteOffOfDeferredDebtIssuanceCost 0us-gaap_WriteOffOfDeferredDebtIssuanceCost
Capitalization of construction in-process related to construction financing lease obligation 25,564us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1 215,013us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1 235,594us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1
Assets acquired under capital lease obligations 9,188us-gaap_CapitalLeaseObligationsIncurred 50,972us-gaap_CapitalLeaseObligationsIncurred 31,101us-gaap_CapitalLeaseObligationsIncurred
Issuances of common stock exercises from employee benefit plans receivable $ 637us-gaap_ConversionOfStockAmountIssued1 $ 0us-gaap_ConversionOfStockAmountIssued1 $ 0us-gaap_ConversionOfStockAmountIssued1