Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (242)	$ (382)	$ (449)	$ (681)
Total stock-based compensation expense included in costs and expenses	42,444	41,350	89,024	72,625
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	26,985	29,949	52,112	49,623
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	158,362		158,362
Weighted-average Recognition Period			2 years 3 months 29 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	14,020	9,732	33,013	19,110
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	102,006		102,006
Weighted-average Recognition Period			2 years 1 month 21 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	1,681	2,051	4,348	4,573
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	4,082		4,082
Weighted-average Recognition Period			6 months 29 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	27,253	25,740	60,153	45,089
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 15,191	$ 15,610	$ 28,871	$ 27,536
Maximum
Share-based Compensation Arrangement by Share-based Payment Award
Maximum percent of employees eligible for partial or full acceleration of equity awards (percent)	5.00%		5.00%