Segment Information (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues from external customers
Product revenues, net	$ 281,309	$ 303,501	$ 373,273	$ 375,375	$ 456,759	$ 419,595	$ 74,535	$ 0	$ 1,333,458	$ 950,889	$ 0
Total revenues	333,994	336,006	418,305	438,737	563,340	659,200	114,424	73,662	1,527,042	1,410,626	143,370
Property and equipment, net	433,609				133,176				433,609	133,176
United States
Revenues from external customers
Total revenues									1,373,516	1,389,568	143,370
Property and equipment, net	400,102				109,480				400,102	109,480
Outside of the United States
Revenues from external customers
Total revenues									153,526	21,058	0
Property and equipment, net	33,507				23,696				33,507	23,696
United Kingdom
Revenues from external customers
Property and equipment, net	30,622				21,377				30,622	21,377
Europe
Revenues from external customers
Total revenues									129,786	20,289	0
Other
Revenues from external customers
Total revenues									23,740	769	0
Property and equipment, net	2,885				2,319				2,885	2,319
Minimum | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	10.00%				10.00%				10.00%	10.00%
Minimum | Accounts Receivable [Member]
Revenues from external customers
Threshold for disclosure percentage	10.00%				10.00%				10.00%	10.00%
Credit Concentration Risk | Amerisource Bergen Drug Corporation | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	32.00%				25.00%				32.00%	25.00%	0.00%
Credit Concentration Risk | Amerisource Bergen Drug Corporation | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage	22.00%				35.00%				22.00%	35.00%
Credit Concentration Risk | McKesson Corporation | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	29.00%				24.00%				29.00%	24.00%	0.00%
Credit Concentration Risk | McKesson Corporation | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage	26.00%				30.00%				26.00%	30.00%
Credit Concentration Risk | Cardinal Health Incorporated | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	15.00%				15.00%				15.00%	15.00%	0.00%
Credit Concentration Risk | Cardinal Health Incorporated | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage					20.00%					20.00%
Credit Concentration Risk | Cardinal Health Incorporated | Maximum [Member] | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage	10.00%								10.00%
Credit Concentration Risk | Janssen Pharmaceutica, N.V. | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage					19.00%					19.00%	21.00%
Credit Concentration Risk | Janssen Pharmaceutica, N.V. | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage	26.00%				10.00%				26.00%	10.00%
Credit Concentration Risk | Janssen Pharmaceutica, N.V. | Maximum [Member] | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	10.00%								10.00%
Credit Concentration Risk | Mitsubishi Tanabe Pharma Corporation | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage											57.00%
Credit Concentration Risk | Mitsubishi Tanabe Pharma Corporation | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage	0.00%								0.00%
Credit Concentration Risk | Mitsubishi Tanabe Pharma Corporation | Maximum [Member] | Revenues, Net [Member]
Revenues from external customers
Concentration risk, percentage	10.00%				10.00%				10.00%	10.00%
Credit Concentration Risk | Mitsubishi Tanabe Pharma Corporation | Maximum [Member] | Accounts Receivable [Member]
Revenues from external customers
Concentration risk, percentage					10.00%					10.00%
INCIVEK
Revenues from external customers
Product revenues, net									1,161,813	950,889	0
KALYDECO
Revenues from external customers
Product revenues, net									$ 171,645	$ 0	$ 0