Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2012

Payables and Accruals [Abstract]

Accrued expenses and other current liabilities

Accrued expenses consisted of the following:

	As of December 31,
	2012		2011
	(in thousands)
Research, development and commercial contract costs	$	63,960	$	66,426
Payroll and benefits	62,140		57,453
Product revenue allowances	69,936		58,201
Royalty payable	29,007		28,603
Unrecognized tax benefits	4,106		4,360
Interest	3,395		3,363
Professional fees	11,226		12,785
Other	21,114		11,996
Total	$	264,884	$	243,187