United States securities and exchange commission logo





                              September 20, 2022

       Reshma Kewalramani
       Chief Executive Officer and President
       Vertex Pharmaceuticals Incorporated
       50 Northern Avenue
       Boston, Massachusetts 02210

                                                        Re: Vertex
Pharmaceuticals Incorporated
                                                            Definitive Proxy
Statement on Schedule 14A
                                                            Filed April 7, 2022
                                                            File No. 000-19319

       Dear Dr. Kewalramani:

             We have limited our review of your most recent definitive proxy
statement to those issues
       we have addressed in our comments.

               Please respond to these comments by confirming that you will
enhance your future proxy
       disclosures in accordance with the topics discussed below as well as any
material developments
       to your risk oversight structure. For guidance, refer to Item 407(h) of
Regulation S-K.

       Definitive Proxy Statement on Schedule 14A filed April 7, 2022

       General

   1.                                                   Please expand your
discussion of the reasons you believe that your leadership structure is
                                                        appropriate, addressing
your specific characteristics or circumstances. In your discussion,
                                                        please also address the
circumstances under which you would consider having the Chair
                                                        and CEO roles filled by
a single individual, when shareholders would be notified of any
                                                        such change, and
whether you will seek prior input from shareholders. Please also
                                                        address how the
experience of your Lead Independent Director is brought to bear in
                                                        connection with your
board   s role in risk oversight.
   2.                                                   Please expand upon the
role that your Lead Independent Director plays in the leadership
                                                        of the board. For
example, please enhance your disclosure to address whether or not your
                                                        Lead Independent
Director may:
                                                            represent the board
in communications with shareholders and other stakeholders;
                                                            require board
consideration of, and/or override your CEO on, any risk matters; or
                                                            provide input on
design of the board itself.
   3.                                                   Please expand upon how
your board administers its risk oversight function. For example,
 Reshma Kewalramani
Vertex Pharmaceuticals Incorporated
September 20, 2022
Page 2
         please disclose:
             the timeframe over which you evaluate risks (e.g., short-term,
intermediate-term, or
             long-term) and how you apply different oversight standards based
upon the
             immediacy of the risk assessed;
             whether you consult with outside advisors and experts to
anticipate future threats and
             trends, and how often you re-assess your risk environment;
             whether you have a Chief Compliance Officer and to whom this
position reports; and
             how your risk oversight process aligns with your disclosure
controls and procedure.

        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Please contact Amanda Ravitz at 202-551-3412 or Barbara Jacobs at
202-551-3735 with
any questions.



FirstName LastNameReshma Kewalramani                         Sincerely,
Comapany NameVertex Pharmaceuticals Incorporated
                                                             Division of
Corporation Finance
September 20, 2022 Page 2                                    Disclosure Review
Program
FirstName LastName