Exhibit 12.1

BIOGEN IDEC INC. AND SUBSIDIARIES

COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES(1)

		Years Ended December 31,
		2004		2003			2002
		(In thousands, except ratios)
Income before income tax provision (benefit)		$	64,093	$	(880,624	)	$	231,522
Fixed charges:
	Interest expense and amortization of original issue discount on all indebtedness		18,499		15,105			16,073
	Interest included in rent expense		5,312		1,943			1,541
Total fixed charges			23,811		17,048			17,614
Income before income tax provision (benefit) and fixed charges			87,904		(863,576	)		249,136
Ratio of earnings (loss) to fixed charges			3.69		—			14.14

(1)  The ratio of earnings to fixed charges was computed by dividing earnings (loss) before income taxes and fixed charges by fixed charges for the periods indicated. Fixed charges include (i) interest expense and amortization of original issue discount on all indebtedness and (ii) a reasonable approximation of the interest factor deemed to be included in rental expense.