Other Consolidated Financial Statement Detail - Accrued Expense and Other (Details) - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items]
Revenue-related reserves for discounts and allowances	$ 935.3	$ 1,276.0	$ 1,198.9	$ 1,051.3
Total accrued expense and other	2,535.2	3,145.3
Component of accrued expense and other
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items]
Revenue-related reserves for discounts and allowances	802.1	1,080.6
Collaboration expense	324.7	389.9
Employee compensation and benefits	345.1	333.8
Royalties and licensing fees	234.7	218.5
Derivative liabilities	10.8	181.5
Current portion of contingent consideration obligations	0.0	149.6
Other	817.8	791.4
Total accrued expense and other	$ 2,535.2	$ 3,145.3