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Fair Value Measurements (Details Textual) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2021
Dec. 31, 2020
Business Acquisition, Contingent Consideration [Line Items]      
Asset impairment charges $ 0 $ 0  
Contingent consideration obligations $ 210,700,000 $ 210,700,000 $ 110,300,000
Technological and Regulatory Success, Probability   10.80%  
3.625% Senior Notes due 2022      
Business Acquisition, Contingent Consideration [Line Items]      
Senior notes interest rate 3.625% 3.625%  
4.050% Senior Notes due 2025      
Business Acquisition, Contingent Consideration [Line Items]      
Senior notes interest rate 4.05% 4.05%  
5.200% Senior Notes due 2045      
Business Acquisition, Contingent Consideration [Line Items]      
Senior notes interest rate 5.20% 5.20%