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Investments in Variable Interest Entities (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Dec. 31, 2014
Investment in Variable Interest Entities (Textual) [Abstract]          
Research and development $ 490,728 $ 447,273 $ 951,277 $ 976,157  
Investment in biotechnology companies that are determined to be unconsolidated variable interest entities 8,500   8,500   $ 7,900
Neurimmune          
Investment in Variable Interest Entities (Textual) [Abstract]          
Remaining potential development milestone payments and royalties on commercial sales under the terms of collaboration agreement     335,000    
Expected milestone payment for initiation of a late stage clinical trial     60,000    
Research and development $ 35,000 $ 10,600 $ 47,800 $ 21,700