EXHIBIT 32.1

                    CERTIFICATION OF CHIEF EXECUTIVE OFFICER
                      AND CHIEF FINANCIAL OFFICER PURSUANT
                TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002*

      Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (18 U.S.C
Section 1350, as adopted), James A.D. Smith, President and Chief Executive
Officer of Genelabs Technologies, Inc. (the "Company"), and Matthew M. Loar,
Chief Financial Officer of the Company, each hereby certifies that, to the best
of his knowledge:

      1. The Company's Quarterly Report on Form 10-Q for the period ended
September 30, 2004, to which this Certification is attached as Exhibit 32.1 (the
"Periodic Report"), fully complies with the requirements of Section 13(a) of the
Securities Exchange Act of 1934, as amended; and

      2. The information contained in the Periodic Report fairly presents, in
all material respects, the financial condition of the Company at the end of the
period covered by the Periodic Report and results of operations of the Company
for the period covered by the Periodic Report.

Dated: November 4, 2004

/S/ JAMES A.D. SMITH                                  /S/ MATTHEW M. LOAR
-------------------------------------                 -------------------------
James A.D. Smith                                      Matthew M. Loar
President and Chief Executive Officer                 Chief Financial Officer

A signed original of this written statement required by Section 906, or other
document authentication, acknowledging, or otherwise adopting the signature that
appears in typed form within the electronic version of this statement required
by Section 906, has been provided to Genelabs Technologies, Inc. and will be
retained by Genelabs Technologies, Inc. and furnished to the Securities and
Exchange Commission ("SEC") or its staff upon request.

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* This certification accompanies the Form 10-Q to which it relates, is not
deemed filed with the SEC and is not to be incorporated by reference into any
filing of the Company under the Securities Act of 1933, as amended, or the
Securities Exchange Act of 1934, as amended (whether made before or after the
date of the Form 10-Q), irrespective of any general incorporation language
contained in such filing.