QuickLinks -- Click here to rapidly navigate through this document

Exhibit 25.1

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM T-1

STATEMENT OF ELIGIBILITY
UNDER THE TRUST INDENTURE ACT OF 1939 OF A
CORPORATION DESIGNATED TO ACT AS TRUSTEE

o CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2)

WELLS FARGO BANK, NATIONAL ASSOCIATION
(Exact name of trustee as specified in its charter)

A National Banking Association (Jurisdiction of incorporation or organization if not a U.S. national bank)	94-1347393 (I.R.S. Employer Identification No.)
101 North Phillips Avenue Sioux Falls, South Dakota (Address of principal executive offices)	57104 (Zip code)

Wells Fargo & Company
Law Department, Trust Section
MAC N9305-175
Sixth Street and Marquette Avenue, 17^th Floor
Minneapolis, Minnesota 55479
(612) 667-4608
(Name, address and telephone number of agent for service)

CURATIVE HEALTH SERVICES, INC.(1)
(Exact name of obligor as specified in its charter)

Minnesota (State or other jurisdiction of incorporation or organization)	51-0467366 (I.R.S. Employer Identification No.)
150 Motor Parkway Hauppauge, New York (Address of principal executive offices)	11788 (Zip code)

10³/4% Senior Notes due 2011
(Title of the indenture securities)

        (1)    See Table 1—List of additional obligors

Table 1

	Guarantor	State of Incorporation	Federal EIN	Address
1.	EBIOCARE.COM	Delaware	77-0473301	1121 Industrial Road San Carlos, CA 94070
2.	APEX THERAPEUTIC CARE, INC	California	95-4677874	31332 Via Colinas, Suite 105-108 Westlake Village, CA 91362
3.	CHS SERVICES, INC.	Delaware	51-0378797	103 Foulk Road, Suite 200 Wilmington, Delaware 19803
4.	CURATIVE HEALTH SERVICES OF NEW YORK, INC.	New York	02-0646252	144 Freeman's Bridge Road Glenville, New York 13202
5.	CRITICAL CARE SYSTEMS, INC.	Delaware	04-3115329	150 Motor Parkway Hauppauge, New York 11788
6.	OPTIMAL CARE PLUS, INC.	Delaware	22-3878209	12761 Darby Brooke Court Woodbridge, Virginia 22192
7.	MEDCARE, INC.	Delaware	22-3891372	107A David Green Road Birmingham, Alabama 35244
8.	CURATIVE PHARMACY SERVICES, INC.	Delaware	57-1160625	150 Motor Parkway Hauppauge, New York 11788
9.	CURATIVE HEALTH SERVICES CO.	Minnesota	41-1503914	150 Motor Parkway Hauppauge, New York 11788
10.	CURATIVE HEALTH SERVICES III CO.	Minnesota	51-0467383	150 Motor Parkway Hauppauge, New York 11788
11.	HEMOPHILIA ACCESS, INC.	Tennessee	62-1557624	100 Winners Circle, Suite 120 Brentwood, Tennessee 37027
12.	INFINITY INFUSION, LLC	Delaware	41-2043158	9701 Richmond Avenue Houston, Texas 77042
13.	INFINITY INFUSION II, LLC	Delaware	04-3673742	9701 Richmond Avenue Houston, Texas 77042
14.	INFINITY INFUSION CARE. LTD.	Texas	76-0391439	9701 Richmond Avenue Houston, Texas 77042

Item 1.    General Information.    Furnish the following information as to the trustee:

(a)

Name and address of each examining or supervising authority to which it is subject.

Comptroller of the Currency
Treasury Department
Washington, D.C.

Federal Deposit Insurance Corporation
Washington, D.C.

Federal Reserve Bank of San Francisco
San Francisco, California 94120

(b)

Whether it is authorized to exercise corporate trust powers.

The trustee is authorized to exercise corporate trust powers.

Item 2.    Affiliations with Obligor.    If the obligor is an affiliate of the trustee, describe each such affiliation.

None with respect to the trustee.

No responses are included for Items 3-14 of this Form T-1 because the obligor is not in default as provided under Item 13.

Item 15.    Foreign Trustee.    Not applicable.

Item 16.    List of Exhibits.    List below all exhibits filed as a part of this Statement of Eligibility.

Exhibit 1.	A copy of the Articles of Association of the trustee now in effect.*
Exhibit 2.	A copy of the Comptroller of the Currency Certificate of Corporate Existence and Fiduciary Powers for Wells Fargo Bank, National Association, dated February 4, 2004.**
Exhibit 3.	See Exhibit 2
Exhibit 4.	Copy of By-laws of the trustee as now in effect.***
Exhibit 5.	Not applicable.
Exhibit 6.	The consent of the trustee required by Section 321(b) of the Act.
Exhibit 7.	A copy of the latest report of condition of the trustee published pursuant to law or the requirements of its supervising or examining authority.****
Exhibit 8.	Not applicable.
Exhibit 9.	Not applicable.

*

Incorporated by reference to the exhibit of the same number to the trustee's Form T-1 filed as exhibit 25 to the Form T-3 dated March 3, 2004 of Trans-Lux Corporation file number 022-28721.

**

Incorporated by reference to the exhibit of the same number to the trustee's Form T-1 filed as exhibit 25 to the Form T-3 dated March 3, 2004 of Trans-Lux Corporation file number 022-28721.

***

Incorporated by reference to the exhibit of the same number to the trustee's Form T-1 filed as exhibit 25 to the Form T-3 dated March 3, 2004 of Trans-Lux Corporation file number 022-28721.

****

Incorporated by reference to the exhibit of the same number to the trustee's Form T-1 filed as exhibit 25 to the form S-4 dated May 25, 2004 of Amkor Technology, Inc. file number 333-115821.

SIGNATURE

        Pursuant to the requirements of the Trust Indenture Act of 1939, as amended, the trustee, Wells Fargo Bank, National Association, a national banking association organized and existing under the laws of the United States of America, has duly caused this statement of eligibility to be signed on its behalf by the undersigned, thereunto duly authorized, all in the City of Minneapolis and State of Minnesota on the 8th day of July 2004.

WELLS FARGO BANK, NATIONAL ASSOCIATION

/s/  TIMOTHY P. MOWDY

Timothy P. Mowdy
Assistant Vice President

EXHIBIT 6

July 8, 2004

Securities and Exchange Commission
Washington, D.C. 20549

Gentlemen:

        In accordance with Section 321(b) of the Trust Indenture Act of 1939, as amended, the undersigned hereby consents that reports of examination of the undersigned made by Federal, State, Territorial, or District authorities authorized to make such examination may be furnished by such authorities to the Securities and Exchange Commission upon its request therefor.

Very truly yours,

WELLS FARGO BANK, NATIONAL ASSOCIATION

/s/  TIMOTHY P. MOWDY

Timothy P. Mowdy
Assistant Vice President

Exhibit 7

Consolidated Report of Condition of

Wells Fargo Bank Minnesota, National Association
of Sixth Street and Marquette Avenue, Minneapolis, MN 55479
And Foreign and Domestic Subsidiaries,
at the close of business December 31, 2003,
filed in accordance with 12 U.S.C. §161 for National Banks.

				Dollar Amounts In Millions
ASSETS
Cash and balances due from depository institutions:
	Noninterest-bearing balances and currency and coin			$	1,322
	Interest-bearing balances				127
Securities:
	Held-to-maturity securities				0
	Available-for-sale securities				2,568
Federal funds sold and securities purchased under agreements to resell:
	Federal funds sold in domestic offices				1,053
	Securities purchased under agreements to resell				0
Loans and lease financing receivables:
	Loans and leases held for sale				14,457
	Loans and leases, net of unearned income		27,715
	LESS: Allowance for loan and lease losses		284
	Loans and leases, net of unearned income and allowance				27,431
Trading Assets					49
Premises and fixed assets (including capitalized leases)					180
Other real estate owned					12
Investments in unconsolidated subsidiaries and associated companies					0
Customers' liability to this bank on acceptances outstanding					22
Intangible assets
	Goodwill				291
	Other intangible assets				9
Other assets					1,281
Total assets				$	48,802
LIABILITIES
Deposits:
	In domestic offices			$	29,890
		Noninterest-bearing	17,097
		Interest-bearing	12,793
	In foreign offices, Edge and Agreement subsidiaries, and IBFs				4
		Noninterest-bearing	0
		Interest-bearing	4
Federal funds purchased and securities sold under agreements to repurchase:
	Federal funds purchased in domestic offices				9,295
	Securities sold under agreements to repurchase				237
Trading liabilities					2
Other borrowed money (includes mortgage indebtedness and obligations under capitalized leases)					4,543
Bank's liability on acceptances executed and outstanding					22
Subordinated notes and debentures					0
Other liabilities					973
Total liabilities				$	44,966
Minority interest in consolidated subsidiaries					0
EQUITY CAPITAL
Perpetual preferred stock and related surplus					0
Common stock					100
Surplus (exclude all surplus related to preferred stock)					2,134
Retained earnings					1,546
Accumulated other comprehensive income					56
Other equity capital components					0
Total equity capital					3,836
Total liabilities, minority interest, and equity capital				$	48,802

        I, Karen B. Martin, Vice President of the above-named bank do hereby declare that this Report of Condition has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true to the best of my knowledge and belief.

Karen B. Martin
Vice President

        We, the undersigned directors, attest to the correctness of this Report of Condition and declare that it has been examined by us and to the best of our knowledge and belief has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true and correct.

Jon R. Campbell
Marilyn A. Dahl	Directors
Gerald B. Stenson

Exhibit 7

Consolidated Report of Condition of

Wells Fargo Bank National Association
of 420 Montgomery Street, San Francisco, CA 94163
And Foreign and Domestic Subsidiaries,
at the close of business December 31, 2003,
filed in accordance with 12 U.S.C. §161 for National Banks.

				Dollar Amounts In Millions
ASSETS
Cash and balances due from depository institutions:
	Noninterest-bearing balances and currency and coin			$	11,411
	Interest-bearing balances				3,845
Securities:
	Held-to-maturity securities				0
	Available-for-sale securities				17,052
Federal funds sold and securities purchased under agreements to resell:
	Federal funds sold in domestic offices				516
	Securities purchased under agreements to resell				109
Loans and lease financing receivables:
	Loans and leases held for sale				14,571
	Loans and leases, net of unearned income		172,511
	LESS: Allowance for loan and lease losses		1,554
	Loans and leases, net of unearned income and allowance				170,957
Trading Assets					6,255
Premises and fixed assets (including capitalized leases)					2,067
Other real estate owned					144
Investments in unconsolidated subsidiaries and associated companies					306
Customers' liability to this bank on acceptances outstanding					68
Intangible assets
	Goodwill				6,814
	Other intangible assets				7,501
Other assets					8,858
Total assets				$	250,474
LIABILITIES
Deposits:
	In domestic offices			$	157,695
		Noninterest-bearing	44,315
		Interest-bearing	113,380
	In foreign offices, Edge and Agreement subsidiaries, and IBFs				16,249
		Noninterest-bearing	6
		Interest-bearing	16,243
Federal funds purchased and securities sold under agreements to repurchase:
	Federal funds purchased in domestic offices				14,685
	Securities sold under agreements to repurchase				1,613
Trading liabilities					4,277
Other borrowed money (includes mortgage indebtedness and obligations under capitalized leases)					18,212
Bank's liability on acceptances executed and outstanding					68
Subordinated notes and debentures					6,742
Other liabilities					7,358
Total liabilities				$	226,899
Minority interest in consolidated subsidiaries					60
EQUITY CAPITAL
Perpetual preferred stock and related surplus					0
Common stock					520
Surplus (exclude all surplus related to preferred stock)					17,709
Retained earnings					4,920
Accumulated other comprehensive income					366
Other equity capital components					0
Total equity capital					23,515
Total liabilities, minority interest, and equity capital				$	250,474

        I, James E. Hanson, Vice President of the above-named bank do hereby declare that this Report of Condition has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true to the best of my knowledge and belief.

James E. Hanson
Vice President

        We, the undersigned directors, attest to the correctness of this Report of Condition and declare that it has been examined by us and to the best of our knowledge and belief has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true and correct.

Carrie L. Tolstedt
Howard Atkins	Directors
John Stumpf

QuickLinks

FORM T-1
SIGNATURE
EXHIBIT 6