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Significant Accounting Policies (Details 7) (USD $)
3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Allocation of stock-based compensation expense        
Stock-based compensation expense $ 2,636,000 $ 2,460,000 $ 5,505,000 $ 4,727,000
Non-vested stock option
       
Allocation of stock-based compensation expense        
Unrecognized estimated non-cash stock-based compensation expense 9,700,000   9,700,000  
Weighted average period over which cost is expected to be recognized     1 year 3 months 18 days  
RSUs
       
Allocation of stock-based compensation expense        
Unrecognized estimated non-cash stock-based compensation expense 3,300,000   3,300,000  
Weighted average period over which cost is expected to be recognized     1 year 10 months 24 days  
Research and development
       
Allocation of stock-based compensation expense        
Stock-based compensation expense 2,252,000 2,073,000 4,798,000 4,008,000
General and administrative
       
Allocation of stock-based compensation expense        
Stock-based compensation expense $ 384,000 $ 387,000 $ 707,000 $ 719,000