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Significant Accounting Policies (Details 3) (USD $)
1 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2013
Jun. 30, 2013
item
Dec. 31, 2012
item
Public Offering      
Shares sold 9,617,869    
Issuance price per share (in dollars per share) $ 19.00 $ 19.00  
Additional shares sold pursuant to option granted to the underwriters 617,869    
Proceeds from issuance of common stock $ 173,200,000 $ 173,223,000  
Underwriting discounts and commissions and other estimated offering expenses 9,500,000    
Consolidation of variable interest entities      
Number of variable interest entities in which the entity is not primary beneficiary   5 6
Carrying value of investments in variable interest entities $ 63,600,000 $ 63,600,000  
Maximum
     
Equity method of accounting      
Ownership percentage   20.00%  
Regulus Therapeutics Inc. | Maximum
     
Equity method of accounting      
Ownership percentage   20.00%