EX-25.1 5 a07-8423_1ex25d1.htm EX-25.1

Exhibit 25.1

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549


FORM T-1

STATEMENT OF ELIGIBILITY
UNDER THE TRUST INDENTURE ACT OF 1939 OF A
CORPORATION DESIGNATED TO ACT AS TRUSTEE


o   CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO
SECTION 305(b) (2)

WELLS FARGO BANK, NATIONAL ASSOCIATION
(Exact name of trustee as specified in its charter)

A National Banking Association

 

94-1347393

(Jurisdiction of incorporation or

 

(I.R.S. Employer

organization if not a U.S. national

 

Identification No.)

bank)

 

 

 

 

 

101 North Phillips Avenue

 

 

Sioux Falls, South Dakota

 

57104

(Address of principal executive offices)

 

(Zip code)

 

Wells Fargo & Company

Law Department, Trust Section

MAC N9305-175

Sixth Street and Marquette Avenue, 17th Floor

Minneapolis, Minnesota 55479

(612) 667-4608

(Name, address and telephone number of agent for service)


Isis Pharmaceuticals, inc.

(Exact name of obligor as specified in its charter)

Delaware

 

33-0336973

(State or other jurisdiction of

 

(I.R.S. Employer

incorporation or organization)

 

Identification No.)

 

 

 

1896 Rutherford Road

 

 

Carlsbad, CA

 

92008

(Address of principal executive offices)

 

(Zip code)

 


2 5/8 % Convertible Subordinated Notes due 2027

(Title of the indenture securities)

 

 




 

Item 1.    General Information.  Furnish the following information as to the trustee:

(a)                                  Name and address of each examining or supervising authority to which it is subject.

Comptroller of the Currency

Treasury Department

Washington, D.C.

Federal Deposit Insurance Corporation

Washington, D.C.

Federal Reserve Bank of San Francisco

San Francisco, California 94120

(b)                                 Whether it is authorized to exercise corporate trust powers.

The trustee is authorized to exercise corporate trust powers.

Item 2.             Affiliations with Obligor.  If the obligor is an affiliate of the trustee, describe each such affiliation.

None with respect to the trustee.

No responses are included for Items 3-14 of this Form T-1 because the obligor is not in default as provided under Item 13.

Item 15.  Foreign Trustee.   Not applicable.

Item 16.  List of Exhibits.               List below all exhibits filed as a part of this Statement of Eligibility.

Exhibit 1.

 

A copy of the Articles of Association of the trustee now in effect.*

Exhibit 2.

 

A copy of the Comptroller of the Currency Certificate of Corporate Existence and Fiduciary Powers for Wells Fargo Bank, National Association, dated February 4, 2004.**

Exhibit 3.

 

See Exhibit 2

Exhibit 4.

 

Copy of By-laws of the trustee as now in effect.***

Exhibit 5.

 

Not applicable.

Exhibit 6.

 

The consent of the trustee required by Section 321(b) of the Act.

Exhibit 7.

 

A copy of the latest report of condition of the trustee published pursuant to law or the requirements of its supervising or examining authority.

Exhibit 8.

 

Not applicable.

Exhibit 9.

 

Not applicable.




 

*      Incorporated by reference to the exhibit of the same number to the trustee’s Form T-1 filed as exhibit 25 to the Form S-4 dated December 30, 2005 of Hornbeck Offshore Services LLC file number 333-130784-06.

**   Incorporated by reference to the exhibit of the same number to the trustee’s Form T-1 filed as exhibit 25 to the Form T-3 dated March 3, 2004 of Trans-Lux Corporation file number 022-28721.

*** Incorporated by reference to the exhibit of the same number to the trustee’s Form T-1 filed as exhibit 25 to the Form S-4 dated May 26, 2005 of Penn National Gaming Inc. file number 333-125274.




SIGNATURE

Pursuant to the requirements of the Trust Indenture Act of 1939, as amended, the trustee, Wells Fargo Bank, National Association, a national banking association organized and existing under the laws of the United States of America, has duly caused this statement of eligibility to be signed on its behalf by the undersigned, thereunto duly authorized, all in the City of Minneapolis and State of Minnesota on the 19th day of March 2007.

 

WELLS FARGO BANK, NATIONAL ASSOCIATION

 

 

 

 

 

 

 

 

/s/ Lynn M. Steiner

 

 

Lynn M. Steiner

 

 

Vice President




EXHIBIT 6

March 19, 2007

Securities and Exchange Commission
Washington, D.C.  20549

Gentlemen:

In accordance with Section 321(b) of the Trust Indenture Act of 1939, as amended, the undersigned hereby consents that reports of examination of the undersigned made by Federal, State, Territorial, or District authorities authorized to make such examination may be furnished by such authorities to the Securities and Exchange Commission upon its request therefor.

 

Very truly yours,

 

 

 

 

 

WELLS FARGO BANK, NATIONAL ASSOCIATION

 

 

 

 

 

 

 

 

/s/ Lynn M. Steiner

 

 

Lynn M. Steiner

 

 

Vice President




EXHIBIT 7

Consolidated Report of Condition of
Wells Fargo Bank National Association
of 101 North Phillips Avenue, Sioux Falls, SD 57104
And Foreign and Domestic Subsidiaries,
at the close of business December 31, 2006, filed in accordance with 12 U.S.C. §161 for National Banks.

 

 

 

 

Dollar Amounts

 

 

 

 

 

In Millions

 

ASSETS

 

 

 

 

 

Cash and balances due from depository institutions:

 

 

 

 

 

Noninterest-bearing balances and currency and coin

 

 

 

$

15,071

 

Interest-bearing balances

 

 

 

1,332

 

Securities:

 

 

 

 

 

Held-to-maturity securities

 

 

 

0

 

Available-for-sale securities

 

 

 

37,720

 

Federal funds sold and securities purchased under agreements to resell:

 

 

 

 

 

Federal funds sold in domestic offices

 

 

 

4,141

 

Securities purchased under agreements to resell

 

 

 

1,130

 

Loans and lease financing receivables:

 

 

 

 

 

Loans and leases held for sale

 

 

 

33,751

 

Loans and leases, net of unearned income

 

252,936

 

 

 

LESS: Allowance for loan and lease losses

 

2,088

 

 

 

Loans and leases, net of unearned income and allowance

 

 

 

250,848

 

Trading Assets

 

 

 

3,060

 

Premises and fixed assets (including capitalized leases)

 

 

 

4,045

 

Other real estate owned

 

 

 

557

 

Investments in unconsolidated subsidiaries and associated companies

 

 

 

419

 

Intangible assets

 

 

 

 

 

Goodwill

 

 

 

8,995

 

Other intangible assets

 

 

 

18,458

 

Other assets

 

 

 

19,144

 

Total assets

 

 

 

$

398,671

 

 

 

 

 

 

 

LIABILITIES

 

 

 

 

 

Deposits:

 

 

 

 

 

In domestic offices

 

 

 

$

272,350

 

Noninterest-bearing

 

76,347

 

 

 

Interest-bearing

 

196,003

 

 

 

In foreign offices, Edge and Agreement subsidiaries, and IBFs

 

 

 

39,196

 

Noninterest-bearing

 

12

 

 

 

Interest-bearing

 

39,184

 

 

 

Federal funds purchased and securities sold under agreements to repurchase:

 

 

 

 

 

Federal funds purchased in domestic offices

 

 

 

4,271

 

Securities sold under agreements to repurchase

 

 

 

5,631

 

 




 

 

 

Dollar Amounts

 

 

 

In Millions

 

Trading liabilities

 

2,145

 

Other borrowed money

 

 

 

(includes mortgage indebtedness and obligations under capitalized leases)

 

7,119

 

Subordinated notes and debentures

 

10,164

 

Other liabilities

 

17,464

 

Total liabilities

 

$

358,340

 

 

 

 

 

Minority interest in consolidated subsidiaries

 

61

 

 

 

 

 

EQUITY CAPITAL

 

 

 

Perpetual preferred stock and related surplus

 

0

 

Common stock

 

520

 

Surplus (exclude all surplus related to preferred stock)

 

24,751

 

Retained earnings

 

14,549

 

Accumulated other comprehensive income

 

450

 

Other equity capital components

 

0

 

Total equity capital

 

40,270

 

Total liabilities, minority interest, and equity capital

 

$

398,671

 

 

 

I, Karen B. Nelson, Vice President of the above-named bank do hereby declare that this Report of Condition has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true to the best of my knowledge and belief.

Karen B. Nelson
Vice President

We, the undersigned directors, attest to the correctness of this Report of Condition and declare that it has been examined by us and to the best of our knowledge and belief has been prepared in conformance with the instructions issued by the appropriate Federal regulatory authority and is true and correct.

Avid Modijtabai
John Stumpf                                                          Directors
Carrie Tolstedt