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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Jun. 30, 2024
Jun. 30, 2023
Revenue:        
Revenue $ 225,250 $ 188,411 $ 344,748 $ 318,935
Expenses:        
Cost of sales 4,164 2,537 6,314 3,880
Research, development and patent 222,064 229,927 436,280 427,740
Selling, general and administrative 65,113 46,142 117,758 91,658
Total operating expenses 291,341 278,606 560,352 523,278
Loss from operations (66,091) (90,195) (215,604) (204,343)
Other income (expense):        
Investment income 25,599 20,792 51,884 39,419
Interest expense (4,490) (2,291) (8,641) (3,899)
Interest expense related to sale of future royalties (18,296) (17,655) (36,254) (33,170)
Gain (loss) on investments (3,533) 718 (1,200) 189
Other income 610 11,183 887 11,414
Loss before income tax expense (66,201) (77,448) (208,928) (190,390)
Income tax expense (64) (7,842) (140) (19,223)
Net loss $ (66,265) $ (85,290) $ (209,068) $ (209,613)
Basic net loss per share (in dollars per share) $ (0.45) $ (0.6) $ (1.43) $ (1.47)
Diluted net loss per share (in dollars per share) $ (0.45) $ (0.6) $ (1.43) $ (1.47)
Shares used in computing basic net loss per share (in shares) 145,958 143,098 145,748 142,918
Shares used in computing diluted net loss per share (in shares) 145,958 143,098 145,748 142,918
Commercial Revenue [Member]        
Revenue:        
Revenue $ 72,036 $ 77,897 $ 131,629 $ 145,664
SPINRAZA Royalties [Member]        
Revenue:        
Revenue 56,743 61,012 95,198 111,258
WAINUA Royalties [Member]        
Revenue:        
Revenue 3,781 0 4,907 0
Other Commercial Revenue [Member]        
Revenue:        
Revenue 11,512 16,885 31,524 34,406
Research and Development Revenue [Member]        
Revenue:        
Revenue 153,214 110,514 213,119 173,271
Collaborative Agreement Revenue [Member]        
Revenue:        
Revenue 141,524 91,013 190,870 129,347
WAINUA Joint Development Revenue [Member]        
Revenue:        
Revenue $ 11,690 $ 19,501 $ 22,249 $ 43,924