EX-99.1 14 a05-2957_1ex99d1.htm EX-99.1

Exhibit 99.1

 

Patents Owned or Licensed by MedImmune, Inc.

 

Product/
Project

 

US Patent
No.

 

Subject Matter

 

Expiration
Date

 

E. coli

 

4,795,803

 

Adhesin antigens

 

1/3/2006

 

 

 

5,804,198

 

Adhesin vaccines

 

9/8/2015

 

 

 

6,291,649

 

Anti-adhesin antibodies

 

3/2/2005

 

 

 

6,500,434

 

Chaperone and Adhesin Proteins: Vaccines, Diagnostic and Methods for Treating Infections

 

4/23/2019

 

 

 

6,737,063

 

FimH adhesin proteins and methods of use

 

7/6/2021

 

Vitaxin

 

5,753,230

 

Use of antibodies anti-avb3 antibodies to inhibit angiogenesis in tumors and inflamed tissue

 

5/19/2015

 

 

 

6,590,079

 

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

1/30/2017

 

 

 

6,531,580

 

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

6/24/2019

 

 

 

6,596,850

 

Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same

 

1/30/2018

 

MEDI-507

 

5,730,979

 

Anti-CD2 antibodies and their use in treating T-cell mediated immune responses

 

3/24/2015

 

 

 

5,951,983

 

Anti-CD2 antibodies and their use in treating T-cell mediated immune responses

 

9/14/2016

 

 

 

5,817,311

 

Use of anti-CD2 antibodies in treating T-cell mediated immune responses

 

10/6/2015

 

 

 

6,849,258

 

Anti-CD2 antibodies and their use in treating T-cell mediated immune responses

 

7/18/2017

 

HPV

 

6,261,765

 

Disassembly/reassembly of Papillomavirus Virus Like Particles

 

9/5/2017

 

 

 

6,165,471

 

HPV capsomeres with reduced assembly capacity

 

7/2/2018

 

 

 

6,153,201

 

Oral Immunization with Papillomavirus Virus Like Particles

 

3/9/2013

 

 

 

6,416,945

 

Disassembly/reassembly of Papillomavirus Virus Like Particles

 

9/5/2017

 

RSV

 

5,824,307

 

SynagisÒ & other anti-RSV antibodies and their use in treating or preventing RSV infection

 

10/20/2015

 

 

 

5,582,827

 

Immunoglobulin from plasma for treatment of RSV

 

12/10/2013

 

 

 

4,800,078

 

Treatment of respiratory disease caused by RSV using human gamma globulin

 

1/24/2006

 

 

 

5,412,077

 

Effective Antibody Titers Against Respiratory Viruses

 

8/4/2020

 

 



 

 

 

6,565,849

 

Methods of Enhancing Activity of Vaccines and Vaccine Compositions

 

3/02/2021

 

 

 

6,818,216

 

Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment

 

11/28/2020

 

Strep

 

5,928,900

 

Pad1 protein

 

7/27/2016

 

 

 

5,981,229

 

DNA encoding Exp1 and PlpA proteins

 

11/9/2016

 

 

 

5,834,278

 

DNA encoding pneumococcal MsrA

 

5/1/2016

 

 

 

6,245,335

 

Streptococcal choline binding proteins

 

5/1/2017

 

 

 

5,736,367

 

Vectors and Prokaryotes which Autocatalytically Delete Resistance

 

4/7/2018

 

 

 

5,798,243

 

Bacterial Peptide Methionine Sulfoxide Reductase an Adhesion Associated Protein, and Antibiotic Therapies

 

5/1/2016

 

 

 

6,420,135

 

Streptococcus pneumoniae polynucleotides and sequences

 

10/03/17

 

 

 

6,503,511

 

Derivatives of Choline Binding Proteins for Vaccines

 

4/6/2019

 

 

 

6,582,706

 

Streptococcus Pneumoniae Protein and Immunogenic Fragments for Vaccine

 

12/21/2019

 

 

 

6,689,369

 

Immunogenic pneumococcal protein and vaccine compositions thereof

 

1/17/2022

(a)

 

 

6,784,164

 

Choline binding proteins for anti-pneumococcal vaccines

 

5/1/2017

 

 

 

6,833,356

 

Pneumococcal protein homologs and fragments for vaccines

 

3/10/2021

(a)

IL-9

 

5,157,112

 

Antibodies which specifically bind mammalian T cell growth factor P40

 

10/20/2009

 

 

 

6,037,149

 

DNA and RNA molecules that encode Met-IL-9 and their use for recombinant production

 

8/23/2016

 

 

 

5,580,753

 

DNA molecules encoding IL-9 and their use for recombinant production

 

12/3/2013

 

 

 

5,734,037

 

Nucleic acid molecules that hybridize to DNA encoding IL-9

 

5/23/2009

 

 

 

5,414,071

 

Human IL-9 protein

 

5/9/2012

 

 

 

5,164,317

 

Method for enhancing proliferation of mast cells using IL-9

 

3/23/2010

 

 

 

5,132,109

 

Method for enhancing IgG production using IL-9 and IL-4

 

10/5/2010

 

 

 

5,246,701

 

Method to inhibit IgE production using anti-IL-9 antibodies or other IL-9 inhibitors

 

10/5/2010

 

 

 

5,962,269

 

Processes and hybridomas for producing anti-IL-9 receptor antibodies

 

10/5/2016

 

 

 

6,261,559

 

Treating asthmatic symptoms using anti-IL-9 antibodies

 

8/23/2016

 

 

 

5,789,237

 

Nucleic acid molecules that hybridize to DNAs encoding human and murine IL-9 receptors

 

8/4/2015

 

 



 

 

 

5,750,377

 

Methods for production of mammalian T cell growth factor P40

 

5/12/2015

 

 

 

5,116,951

 

IL-9 receptor protein

 

9/19/2010

 

 

 

5,587,302

 

Nucleic acid molecules encoding mammalian T cell growth factor P40

 

12/24/2013

 

 

 

5,208,218

 

Mammalian T cell growth factor P40 protein

 

5/4/2010

 

 

 

5,180,678

 

Methods of detecting IL-9

 

9/19/2010

 

 

 

6,602,850

 

Method of treating asthma using soluble IL-9 receptor variants

 

8/23/2016

 

 

 

6,645,492

 

Asthma associated factors as targets for treating atopic allergies including asthma and related disorders

 

8/23/2016

 

Ethyol

 

5,292,497

 

Improving toxicity profiles in chemotherapy

 

3/29/2011

 

 

 

5,424,471

 

Process for preparing crystalline forms

 

7/13/2012

 

 

 

5,591,731

 

Dosage forms of crystalline amifostine

 

7/31/2012

 

 

 

5,824,664

 

Agents and methods for inhibiting HIV viral and protein expression using compounds that belong to a family which contains amifostine

 

10/20/2015

 

 

 

5,846,958

 

Methods of stimulating hematopoietic progenitor cells using a compound that belong to a family which contains amifostine

 

12/8/2015

 

 

 

5,906,984

 

Methods of stimulating hematopoietic progenitor cells using specific compounds, which include amifostine

 

2/17/2015

 

 

 

5,994,409

 

Methods of treating toxicities associated with chemotherapy, a method of treating a nephrodisorder, and a method of treating xerostomia, all of which use a compound that belongs to a family which contains amifostine

 

12/9/2017

 

 

 

6,051,563

 

Subcutaneous administration, method of protecting against toxicities associated with ionizing radiation

 

2/12/2017

 

 

 

6,127,351

 

Methods of treating or protecting against toxicities associated with chemotherapy using a specific dosing regime, a method of stimulating bone marrow growth, and a method of treating myelodysplastic syndrome, all of which use a compound that belongs to a family which contains amifostine

 

2/12/2017

 

 

 

6,218,377

 

Methods of treating or protecting against toxicities associated with specific chemotherapy agents, and a method of protecting normal tissue in cancer patients, both of which use a compound that belongs to a family which contains amifostine

 

2/12/2017

 

 

 

6,239,119

 

Methods of treating damaged or infected mucosal tissue using a compounds that belongs to a family which contains amifostine

 

4/26/2019

 

 

 

6,384,259

 

Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same

 

11/16/2018

 

 



 

 

 

6,407,278

 

Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same

 

11/16/2018

 

 

 

6,489,312

 

Novel Pharmaceutical Formulations Comprising Aminoalkyl Phosphorothioates

 

6/15/2019

 

 

 

6,586,476

 

Methods for Treatment of Neuro and Nephro Disorders and Therapeutic Toxicities Using Aminothiol Compounds

 

12/09/2017

 

 

 

6,573,253

 

Methods of the Administration of Amifostine and Related Compounds

 

2/12/2017

 

 

 

6,753,323

 

Topical administration of Amifostine and Related Compounds

 

9/27/2019

(a)

NeuTrexin

 

5,716,960

 

Cystalline glucuronate hydrate salt

 

2/10/2015

 

 

 

4,853,221

 

Method for treating non-small cell lung cancer, head and neck cancers and breast cancer

 

8/1/2006

 

 

 

6,017,921

 

Crystalline glucuronate salt

 

1/13/2015

 

 

 

6,017,922

 

Thermally stable crystalline non-salts

 

5/18/2018

 

 

 

6,258,821

 

Trimetrexate ascorbate and compositions comprising trimetrexate and ascorbic acid

 

4/26/2019

 

 

 

6,258,952

 

Methods of producing monohydrate

 

5/18/2018

 

 

 

4,694,007

 

Use of Trimetrexate as Antiparasitic Agent

 

9/15/2006

 

 

 

4,677,219

 

Substituted Benzonitriles

 

7/17/2006

 

 

 

5,160,727

 

Tumor Cell Sensitization Method

 

3/21/2010

 

 

 

6,576,635

 

Novel Compositions Comprising Trimetrexate

 

10/26/2019

 

PALA

 

5,491,135

 

Methods of treating a viral infections (e.g., hepatitis B and C and secondary to HIV 1)

 

2/13/2013

 

Platinum

 

4,895,935

 

Platinum Pharmaceuticals

 

1/23/2007

 

 

 

4,895,936

 

Platinum Pharmaceuticals

 

1/23/2007

 

 

 

4,957,481

 

Photodynamic therapeutic technique

 

9/18/2007

 

CMV

 

6,291,236

 

Human CMV sequences and attenuated viruses

 

3/31/2015

 

 

 

5,925,751

 

Human CMV sequences and attenuated viruses

 

3/31/2015

 

 

 

5,721,354

 

Human CMV sequences and attenuated viruses

 

3/31/2015

 

 

 

6,040,170

 

Human CMV sequences and attenuated viruses

 

3/31/2015

 

 

 

6,635,477

 

Human CMV sequences and attenuated viruses

 

3/31/2015

 

EBV

 

6,054,130

 

Non-splicing variants of EBV gp350 protein and gene

 

4/18/2014

 

 

 

5,824,508

 

Non-splicing variants of EBV gp350 protein and gene

 

4/18/2014

 

 



 

 

 

6,458,364

 

Non-Splicing Variants of GP350/220

 

4/18/2014

 

 

 

6,692,749

 

Non-Splicing Variants of GP350/220

 

4/18/2014

 

Influenza

 

5,690,937

 

Temperature sensitive mutants of influenza

 

6/5/2015

 

 

 

6,090,391

 

Recombinant tryptophan mutants of influenza PB2 gene

 

2/23/2016

 

 

 

6,322,967

 

Recombinant tryptophan mutants of influenza PB2 gene

 

2/23/2016

 

 

 

6,528,064

 

Recombinant tryptophan mutants of influenza

 

2/23/2016

 

 

 

6,843,996

 

Recombinant Temperature sensitive mutants of influenza

 

6/5/15

 

HSV

 

4,769,331

 

Recombinant herpes simplex cloning methods and materials

 

9/6/2005

 

 

 

4,859,587

 

Recombinant herpes simplex vectors and vaccines

 

8/22/2006

 

 

 

5,288,641

 

Herpes simplex as a vector

 

2/22/2011

 

 

 

5,328,688

 

Recombinant herpes simplex with 34.5 gene knockout

 

6/12/2011

 

 

 

5,599,691

 

Herpes simplex as a vector

 

2/4/2014

 

 

 

5,641,651

 

Synthetic HSV promoters and uses

 

6/24/2014

 

 

 

5,714,153

 

Recombinant herpes simplex vaccines and vectors

 

12/23/2012

 

 

 

5,922,328

 

Gamma 34.5 mutants of herpes simplex viruses

 

9/11/2016

 

 

 

6,071,692

 

Herpes simplex as a gene expression vector and vaccine

 

6/4/2004

 

 

 

6,120,773

 

Gamma 34.5 gene modification of herpes simplex viruses

 

9/19/2017

 

Negative Stranded RNA Viruses

 

5,166,057

 

Recombinant negative strand RNA viruses

 

11/24/2009

 

 

 

5,578,473

 

Recombinant negative strand RNA viruses

 

11/24/2009

 

 

 

5,786,199

 

Recombinant negative strand RNA viruses and vaccines

 

7/28/2015

 

 

 

5,820,871

 

Recombinant negative strand RNA viruses – bicistronic

 

10/13/2015

 

 

 

5,840,520

 

Recombinant negative strand RNA virus expression systems

 

8/28/2009

 

 

 

5,854,037

 

Recombinant negative strand RNA viruses

 

12/29/2015

 

 

 

6,001,634

 

Recombinant negative strand RNA viruses

 

8/28/2009

 

 

 

6,022,726

 

Attenuated negative strand RNA viruses and methods

 

2/8/2017

 

 

 

6,316,243

 

Recombinant attenuated double strand RNA viruses

 

11/13/2018

 

 

 

6,764,685

 

Recombinant parainfluenza virus expression systems and vaccines

 

3/21/2020

 

 

 

6,811,784

 

Recombinant parainfluenza virus expression systems and vaccines

 

3/21/2021

 

 



 

VZV

 

6,087,170

 

VZV gene and mutant VZV viruses

 

4/28/2014

 

 

 

6,713,296

 

VZV gene, mutant VZV and immunogenic compositions

 

4/28/2014

 

HMGB1

 

6,468,533

 

Antagonists of HMG1 for treating inflammatory conditions

 

2/11/2019

 

 

 

6,448,223

 

Antagonists of HMG1 for treating inflammatory conditions

 

2/11/2019

 

 

 

6,303,321

 

Antagonists of HMG1 for treating inflammatory conditions

 

2/11/2019

 

IFNα IFNR1

 

5,889,151

 

Purified human alpha interferon receptor

 

3/30/2016

 

 

 

5,886,153

 

Antibodies directed against the alpha interferon receptor

 

6/6/2016

 

 

 

5,731,169

 

cDNA fragment coding the alpha interferon receptor gene and process for the preparation of a corresponding protein

 

6/6/2015

 

 

 

5,861,258

 

Use of the alpha interferon receptor and cells which express the receptor, for identification of alpha interferon agonists

 

6/6/2016

 

 

 

5,919,453

 

Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon

 

12/5/2016

 

 

 

6,787,634

 

Isolated peptide or polypeptide of the extracellular portion of the human interferon receptor (IFN-R)

 

12/6/2014

 

 

 

6,475,983

 

Water-soluble polypeptides having a high affinity for alpha and beta interferons

 

11/5/2019

 

 


(a) Calculation of expiration date includes patent term adjustment