EX-99.3 22 a2104577zex-99_3.htm EXHIBIT 99.3
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Exhibit 99.3


U.S. Patents Owned or Licensed by MedImmune, Inc.*

Product/ Project
   US Patent
No.
   Subject Matter
   Expiration Date
E. coli   4,795,803   Adhesin antigens   1/3/2006
    5,804,198   Adhesin vaccines   9/8/2015
    6,291,649   Anti-adhesin antibodies   3/2/2005
    6,500,434   Chaperone and Adhesin Proteins: Vaccines, Diagnostic and Methods for Treating Infections   4/23/2019
Vitaxin   5,753,230   Use of antibodies anti- avb3 antibodies to inhibit angiogenesis in tumors and inflamed tissue   5/19/2015
MEDI-507   5,730,979   Anti-CD2 antibodies and their use in treating T-cell mediated immune responses   3/24/2015
    5,951,983   Anti-CD2 antibodies and their use in treating T-cell mediated immune responses   9/14/2016
    5,817,311   Use of anti-CD2 antibodies in treating T-cell mediated immune responses   10/6/2015
HPV   6,228,368   Capsomeres containing HPV L1 protein and their use in preventing and treating HPV infection   10/6/2017
    6,066,324   HPV VLPs containing L1 protein with deletions   10/9/2015
    6,261,765   Disassembly/reassembly of Papillomavirus Virus Like Particles   9/5/2017
    6,165,471   HPV capsomeres with reduced assembly capacity   7/2/2018
    6,153,201   Oral Immunization with Papillomavirus Virus Like Particles   3/9/2013
    6,361,778   Papillomavirus Like Particles, Fusion Proteins as well as Processes for Their Production   9/16/2019
    6,416,945   Disassembly/reassembly of Papillomavirus Virus Like Particles   9/5/2017
RSV   5,824,307   Synagis® & other anti-RSV antibodies and their use in treating or preventing RSV infection   10/20/2015
    5,582,827   Immunoglobulin from plasma for treatment of RSV   12/10/2013
    4,800,078   Treatment of respiratory disease caused by RSV using human gamma globulin   1/24/2006
    5,412,077   Effective Antibody Titers Against Respiratory Viruses   8/4/2020
Strep   5,928,900   Pad1 protein   7/27/2016
    5,981,229   DNA encoding Exp1 and PlpA proteins   11/9/2016
    5,834,278   DNA encoding pneumococcal MsrA   5/1/2016
    6,245,335   Streptococcal choline binding proteins   5/1/2017
    5,736,367   Vectors and Prokaryotes which Autocatalytically Delete Resistance   4/7/2018
    5,798,243   Bacterial Peptide Methionine Sulfoxide Reductase an Adhesion Associated Protein, and Antibiotic Therapies   5/1/2016
    6,420,135   Streptococcus pneumoniae polynucleotides and sequences   10/03/17
    6,503,511   Derivatives of Choline Binding Proteins for Vaccines   4/6/2019
IL-9   5,157,112   Antibodies which specifically bind mammalian T cell growth factor P40   10/20/2009
    6,037,149   DNA and RNA molecules that encode Met-IL-9 and their use for recombinant production   8/23/2016
    5,580,753   DNA molecules encoding IL-9 and their use for recombinant production   12/3/2013
    5,734,037   Nucleic acid molecules that hybridize to DNA encoding IL-9   5/23/2009
    5,414,071   Human IL-9 protein   5/9/2012
    5,164,317   Method for enhancing proliferation of mast cells using IL-9   3/23/2010
    5,132,109   Method for enhancing IgG production using IL-9 and IL-4   10/5/2010
    5,246,701   Method to inhibit IgE production using anti-IL-9 antibodies or other IL-9 inhibitors   10/5/2010
    5,962,269   Processes and hybridomas for producing anti-IL-9 receptor antibodies   10/5/2016
    6,261,559   Treating asthmatic symptoms using anti-IL-9 antibodies   8/23/2016
    5,789,237   Nucleic acid molecules that hybridize to DNAs encoding human and murine IL-9 receptors   8/4/2015
    5,750,377   Methods for production of mammalian T cell growth factor P40   5/12/2015
    5,116,951   IL-9 receptor protein   9/19/2010
    5,587,302   Nucleic acid molecules encoding mammalian T cell growth factor P40   12/24/2013
    5,208,218   Mammalian T cell growth factor P40 protein   5/4/2010
    5,180,678   Methods of detecting IL-9   9/19/2010
Ethyol   5,424,471   Process for preparing crystalline forms   7/13/2012
    5,591,731   Dosage forms of crystalline amifostine   7/31/2012
    5,824,664   Agents and methods for inhibiting HIV viral and protein expression using compounds that belong to a family which contains amifostine   10/20/2015
    5,846,958   Methods of stimulating hematopoietic progenitor cells using a compound that belong to a family which contains amifostine   12/8/2015
    5,906,984   Methods of stimulating hematopoietic progenitor cells using specific compounds, which include amifostine   2/17/2015
    5,994,409   Methods of treating toxicities associated with chemotherapy, a method of treating a nephrodisorder, and a method of treating xerostomia, all of which use a compound that belongs to a family which contains amifostine   12/9/2017
    6,051,563   Subcutaneous administration, method of protecting against toxicities associated with ionizing radiation   2/12/2017
    6,127,351   Methods of treating or protecting against toxicities associated with chemotherapy using a specific dosing regime, a method of stimulating bone marrow growth, and a method of treating myelodysplastic syndrome, all of which use a compound that belongs to a family which contains amifostine   2/12/2017
    6,218,377   Methods of treating or protecting against toxicities associated with specific chemotherapy agents, and a method of protecting normal tissue in cancer patients, both of which use a compound that belongs to a family which contains amifostine   2/12/2017
    6,239,119   Methods of treating damaged or infected mucosal tissue using a compounds that belongs to a family which contains amifostine   4/26/2019
    6,384,259   Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same   11/16/2018
    6,407,278   Stable Amorphous Amifostine Composition and Methods for the Preparation and Use of the Same   11/16/2018
    6,489,312   Novel Pharmaceutical Formulations Comprising Aminoalkyl Phosphorothioates   6/15/2019
NeuTrexin   5,716,960   Cystalline glucuronate hydrate salt   2/10/2015
    6,017,921   Crystalline glucuronate salt   1/13/2015
    6,017,922   Thermally stable crystalline non-salts   5/18/2018
    6,258,821   Trimetrexate ascorbate and compositions comprising trimetrexate and ascorbic acid   4/26/2019
    6,258,952   Methods of producing monohydrate   5/18/2018
    4,376,858   2,4-Diamino-5-methyl-6-[(3,4,5-
trimethoxyanilino)methyl]quinazoline salts		   10/31/2004
    4,694,007   Use of Trimetrexate as Antiparasitic Agent   9/15/2006
    4,677,219   Substituted Benzonitriles   7/17/2006
    5,160,727   Tumor Cell Sensitization Method   3/21/2010
PALA   5,491,135   Methods of treating a viral infections (e.g., hepatitis B and C and secondary to HIV 1)   2/13/2013
Platinum   4,895,935   Platinum Pharmaceuticals   1/23/2007
CMV   6,291,236   Human CMV sequences and attenuated viruses   3/31/2015
    5,925,751   Human CMV sequences and attenuated viruses   3/31/2015
    5,721,354   Human CMV sequences and attenuated viruses   3/31/2015
    6,040,170   Human CMV sequences and attenuated viruses   3/31/2015
EBV   4,707,358   Epstein-Barr virus gp350 subunit protein vaccine   11/17/2004
    6,054,130   Non-splicing variants of EBV gp350 protein and gene   4/18/2014
    5,824,508   Non-splicing variants of EBV gp350 protein and gene   4/18/2014
    6,458,364   Non-Splicing Variants of GP350/220   04/24/2020
Influenza   5,690,937   Temperature sensitive mutants of influenza   6/5/2015
    6,090,391   Recombinant tryptophan mutants of influenza PB2 gene   2/23/2016
    6,322,967   Recombinant tryptophan mutants of influenza PB2 gene   2/23/2016
HSV   4,554,159   Vaccine against HSV-1 and HSV-2   11/19/2002
    4,769,331   Recombinant herpes simplex cloning methods and materials   9/6/2005
    4,859,587   Recombinant herpes simplex vectors and vaccines   8/22/2006
    5,288,641   Herpes simplex as a vector   2/22/2011
    5,328,688   Recombinant herpes simplex with 34.5 gene knockout   6/12/2011
    5,599,691   Herpes simplex as a vector   2/4/2014
    5,641,651   Synthetic HSV promoters and uses   6/24/2014
    5,714,153   Recombinant herpes simplex vaccines and vectors   12/23/2012
    5,846,707   Herpes simplex as a vector   6/4/2004
    5,922,328   Gamma 34.5 mutants of herpes simplex viruses   9/11/2016
    6,071,692   Herpes simplex as a gene expression vector and vaccine   6/4/2004
    6,120,773   Gamma 34.5 gene modification of herpes simplex viruses   9/19/2017
    6,172,047   Herpes viruses modified for use as cancer treatment   1/9/2018
Negative Stranded RNA Viruses   5,166,057   Recombinant negative strand RNA viruses   11/24/2009
    5,578,473   Recombinant negative strand RNA viruses   11/24/2009
    5,786,199   Recombinant negative strand RNA viruses and vaccines   7/28/2015
    5,820,871   Recombinant negative strand RNA viruses — bicistronic   10/13/2015
    5,854,037   Recombinant negative strand RNA viruses   12/29/2015
    6,001,634   Recombinant negative strand RNA viruses   8/28/2009
    6,022,726   Attenuated negative strand RNA viruses and methods   2/8/2017
    6,316,243   Recombinant attenuated double strand RNA viruses   11/13/2018
    5,840,520   Recombinant RSV viruses   11/24/2015
VZV   6,087,170   VZV gene and mutant VZV viruses   4/28/2014
*
The Company encourages any interested investor to obtain an independent legal analysis of the precise scope of the claims of the patents listed above.


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U.S. Patents Owned or Licensed by MedImmune, Inc.