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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QqUsEcfIu+k6qbMUev8h6gsr5b6zQHmG+nB0UENG4/yKHojNOnOvTI5rO8W6DUp6
 v6A/mxF7mnutskkoarRPdA==

<SEC-DOCUMENT>0000873591-06-000060.txt : 20060523
<SEC-HEADER>0000873591-06-000060.hdr.sgml : 20060523
<ACCEPTANCE-DATETIME>20060523161659
ACCESSION NUMBER:		0000873591-06-000060
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060522
FILED AS OF DATE:		20060523
DATE AS OF CHANGE:		20060523

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Greenleaf Peter
		CENTRAL INDEX KEY:			0001363683

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19131
		FILM NUMBER:		06861627

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		3013985537

	MAIL ADDRESS:	
		STREET 1:		ONE MEDIMMUNE WAY
		CITY:			GAITHERSBURG
		STATE:			MD
		ZIP:			20878

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDIMMUNE INC /DE
		CENTRAL INDEX KEY:			0000873591
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				521555759
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		35 W WATKINS MILL RD
		CITY:			GAITHERSBURG
		STATE:			MD
		ZIP:			20878
		BUSINESS PHONE:		3014170770

	MAIL ADDRESS:	
		STREET 1:		35 W WATKINS MILL ROAD
		CITY:			GAITHERSBURG
		STATE:			MD
		ZIP:			20878
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form32006_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-05-22</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000873591</issuerCik>
        <issuerName>MEDIMMUNE INC /DE</issuerName>
        <issuerTradingSymbol>MEDI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001363683</rptOwnerCik>
            <rptOwnerName>Greenleaf Peter</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE MEDIMMUNE WAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GAITHERSBURG</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20878</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP, Sales &amp; Marketing</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>/s/Atul Saran, Attorney-in-Fact</signatureName>
        <signatureDate>2006-05-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----