Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Jun. 30, 2021	Dec. 31, 2020
Payables And Accruals [Abstract]
Accrued contract manufacturing costs	$ 70,453	$ 36,543
Product revenue related reserves	49,153	42,618
Accrued milestone and license expense	38,109	9,380
Accrued employee compensation costs	31,222	50,803
Accrued clinical and pre-clinical costs	25,284	22,169
Accrued royalties	9,201	7,793
Accrued professional fees	8,648	10,221
Accrued collaboration cost sharing	1,494	3,516
Accrued property and equipment	1,186	4,993
Accrued interest expense	1,045	1,045
Other	4,346	4,472
Total accrued expenses	$ 240,141	$ 193,553