Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Payables And Accruals [Abstract]
Product revenue related reserves	$ 48,448	$ 42,618
Accrued contract manufacturing costs	34,556	36,543
Accrued clinical and pre-clinical costs	24,580	22,169
Accrued employee compensation costs	23,520	50,803
Accrued professional fees	10,990	10,221
Accrued milestone expense	9,377	9,380
Accrued collaboration cost sharing	8,962	3,516
Accrued royalties	8,019	7,793
Accrued property and equipment	5,056	4,993
Accrued interest expense	3,182	1,045
Other	3,946	4,472
Total accrued expenses	$ 180,636	$ 193,553