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Summary of Other Non-current Assets (Detail) - USD ($)
$ in Thousands
Mar. 31, 2021
Dec. 31, 2020
Prepaid Expense And Other Assets Noncurrent [Abstract]    
Manufacturing-related deposits and prepaids $ 156,413 $ 148,525
Strategic investments 40,640 38,799
Restricted cash and investments 9,315 9,315
Prepaid clinical expenses 2,124 3,395
Other 3,092 3,669
Total other non-current assets $ 211,584 $ 203,703