Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Payables And Accruals [Abstract]
Accrued employee compensation costs	$ 50,803	$ 43,240
Product revenue related reserves	42,618	45,249
Accrued contract manufacturing costs	36,543	27,622
Accrued clinical and pre-clinical costs	22,169	18,010
Accrued professional fees	10,221	10,707
Accrued milestone expense	9,380	18,390
Accrued royalties	7,793	6,301
Accrued property and equipment	4,993	1,181
Accrued collaboration cost-sharing	3,516	9,000
Accrued interest expense	1,045	1,045
Other	4,472	4,782
Total accrued expenses	$ 193,553	$ 185,527