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Summary of Other Non-current Assets (Detail) - USD ($)
$ in Thousands
Dec. 31, 2020
Dec. 31, 2019
Prepaid Expense And Other Assets Noncurrent [Abstract]    
Manufacturing-related deposits and prepaids $ 148,525 $ 122,091
Strategic investments 38,799 31,937
Restricted cash and investments 9,315 9,566
Prepaid clinical expenses 3,395 4,665
Other 3,669 5,600
Total other non-current assets $ 203,703 $ 173,859