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Summary of Other Non-current Assets (Detail) - USD ($)
$ in Thousands
Sep. 30, 2020
Dec. 31, 2019
Prepaid Expense And Other Assets Noncurrent [Abstract]    
Manufacturing-related deposits and prepaids $ 152,632 $ 122,091
Strategic investments 32,769 31,937
Restricted cash and investments 9,566 9,566
Prepaid clinical expenses 4,248 4,665
Other 2,632 5,600
Total other non-current assets $ 201,847 $ 173,859