Summary of Accrued Expenses (Detail) - USD ($) $ in Thousands	Jun. 30, 2020	Dec. 31, 2019
Payables And Accruals [Abstract]
Product revenue related reserves	$ 43,469	$ 45,249
Accrued employee compensation costs	28,643	43,240
Accrued contract manufacturing costs	22,307	27,622
Accrued clinical and pre-clinical costs	19,281	18,010
Accrued milestone expense	9,643	18,390
Accrued professional fees	9,585	10,707
Accrued property and equipment	8,792	1,181
Accrued royalties	7,053	6,301
Accrued collaboration cost sharing	3,918	9,000
Accrued interest expense	1,045	1,045
Other	5,352	4,782
Total accrued expenses	$ 159,088	$ 185,527