Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive (Loss) Gain [Member]	Accumulated Deficit [Member]
BALANCE at Dec. 31, 2016	$ 336,691	$ 5	$ 1,503,126	$ (120)	$ (1,166,320)
BALANCE (in shares) at Dec. 31, 2016		54,759,000
Exercise of options for common stock	$ 13,799		13,799
Exercise of options for common stock, shares	792,845	793,000
Grant of restricted stock awards and vest of restricted stock units, net of cancellations, shares		400,000
Shares withheld for taxes	$ (2,227)		(2,227)
Shares withheld for taxes, shares		(60,000)
Issuance of common stock for cash, net of offering costs	353,959	$ 1	353,958
Issuance of common stock for cash, net of offering costs, shares		8,798,000
Issuance of common stock under employee stock purchase plan	1,425		1,425
Issuance of common stock under employee stock purchase plan, shares		102,000
Equity component of convertible notes	156,953		156,953
Purchase of capped call share options	(50,901)		(50,901)
Stock-based compensation	30,465		30,465
Unrealized gain (loss) from available-for-sale securities	(259)			(259)
Net loss	(50,688)				(50,688)
BALANCE at Dec. 31, 2017	789,217	$ 6	2,006,598	(379)	(1,217,008)
BALANCE (in shares) at Dec. 31, 2017		64,792,000
Exercise of options for common stock	$ 47,916		47,916
Exercise of options for common stock, shares	2,119,306	2,119,000
Grant of restricted stock awards and vest of restricted stock units, net of cancellations, shares		58,000
Shares withheld for taxes	$ (9,061)		(9,061)
Shares withheld for taxes, shares		(79,000)
Issuance of common stock for cash, net of offering costs	513,409	$ 1	513,408
Issuance of common stock for cash, net of offering costs, shares		4,107,000
Issuance of common stock under employee stock purchase plan	2,306		2,306
Issuance of common stock under employee stock purchase plan, shares		75,000
Stock-based compensation	50,127		50,127
Unrealized gain (loss) from available-for-sale securities	280			280
Net loss	(361,918)				(361,918)
BALANCE at Dec. 31, 2018	$ 1,032,276	$ 7	2,611,294	(99)	(1,578,926)
BALANCE (in shares) at Dec. 31, 2018		71,072,000
Exercise of options for common stock, shares	1,055,715
Exercise of options and stock appreciation rights for common stock	$ 31,522		31,522
Exercise of options and stock appreciation rights for common stock, shares		1,125,000
Grant of restricted stock awards and vest of restricted stock units, net of cancellations, shares		68,000
Shares withheld for taxes	(9,135)		(9,135)
Shares withheld for taxes, shares		(78,000)
Issuance of common stock for cash, net of offering costs	365,354	$ 1	365,353
Issuance of common stock for cash, net of offering costs, shares		2,604,000
Issuance of common stock for collaboration agreement	29,415		29,415
Issuance of common stock for collaboration agreement, shares		302,000
Issuance of common stock under employee stock purchase plan	5,079		5,079
Issuance of common stock under employee stock purchase plan, shares		92,000
Stock-based compensation	78,602		78,602
Unrealized gain (loss) from available-for-sale securities	149			149
Net loss	(715,075)				(715,075)
BALANCE at Dec. 31, 2019	$ 818,187	$ 8	$ 3,112,130	$ 50	$ (2,294,001)
BALANCE (in shares) at Dec. 31, 2019		75,185,000