FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

12 Months Ended

Dec. 31, 2019

Quarterly Financial Information Disclosure [Abstract]

FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

23. FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

	2019 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenues:
Product, net	$	100,113		$	99,041		$	94,668		$	87,011
Total revenues		100,113			99,041			94,668			87,011
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)		15,567			13,037			15,919			12,063
Research and development		223,141			133,949			113,266			90,553
Selling, general and administrative		81,424			75,429			67,393			60,566
Acquired in-process research and development		—			—			173,240			—
Settlement and license charges		10,000			—			—			—
Amortization of in-licensed rights		200			216			217			216
Total cost and operating expenses		330,332			222,631			370,035			163,398
Operating loss		(230,219	)		(123,590	)		(275,367	)		(76,387	)
Other loss:
Other expense, net		(4,773	)		(2,510	)		(862	)		(172	)
Other loss		(4,773	)		(2,510	)		(862	)		(172	)
Loss before income tax expense		(234,992	)		(126,100	)		(276,229	)		(76,559	)
Income tax expense		711			226			174			84
Net loss	$	(235,703	)	$	(126,326	)	$	(276,403	)	$	(76,643	)
Net loss per share - basic and diluted	$	(3.16	)	$	(1.70	)	$	(3.74	)	$	(1.07	)
Weighted average number of shares of common stock used in    computing basic and diluted net loss per share		74,557			74,177			73,958			71,731

	2018 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenues:
Product, net	$	84,415		$	78,486		$	73,529		$	64,604
Total revenues		84,415			78,486			73,529			64,604
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)		13,135			8,741			6,735			5,582
Research and development		146,207			86,584			122,848			46,204
Selling, general and administrative		64,220			53,044			47,156			43,341
Amortization of in-licensed rights		216			216			217			216
Total cost and operating expenses		223,778			148,585			176,956			95,343
Operating loss		(139,363	)		(70,099	)		(103,427	)		(30,739	)
Other loss:
Interest expense and other, net		(2,311	)		(6,968	)		(5,218	)		(4,485	)
Total other loss		(2,311	)		(6,968	)		(5,218	)		(4,485	)
Loss before income (benefit) tax expense		(141,674	)		(77,067	)		(108,645	)		(35,224	)
Income tax (benefit) expense		(779	)		(674	)		622			139
Net loss	$	(140,895	)	$	(76,393	)	$	(109,267	)	$	(35,363	)
Net loss per share - basic and diluted	$	(2.05	)	$	(1.15	)	$	(1.67	)	$	(0.55	)
Weighted average number of shares of common stock used in    computing basic and diluted net loss per share		68,653			66,209			65,484			64,631