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Summary of Aggregate Non-Cancelable Contractual Obligations Arising from Manufacturing Obligations (Detail) - Manufacturing Supply Agreement [Member] - Paragon [Member]
$ in Thousands
Sep. 30, 2019
USD ($)
Commitments And Contingencies [Line Items]  
2019 (October - December) $ 99,583
2020 264,955
2021 168,690
2022 57,204
2023 57,244
Thereafter 202,750
Total manufacturing commitments $ 850,426