Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Product, net	$ 87,011	$ 64,604
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 87,011	$ 64,604
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	12,063	5,582
Research and development	90,553	46,204
Selling, general and administrative	60,566	43,341
Amortization of in-licensed rights	216	216
Total cost and expenses	163,398	95,343
Operating loss	(76,387)	(30,739)
Other loss:
Interest expense and other, net	(172)	(4,485)
Other loss	(172)	(4,485)
Loss before income tax expense	(76,559)	(35,224)
Income tax expense	84	139
Net loss	(76,643)	(35,363)
Other comprehensive income (loss):
Unrealized gain (loss) on cash equivalents and short-term investments	118	(264)
Total other comprehensive income (loss)	118	(264)
Comprehensive loss	$ (76,525)	$ (35,627)
Net loss per share - basic and diluted	$ (1.07)	$ (0.55)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	71,731	64,631