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Reconciliation Between Effective Tax Rate and Federal Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]      
Federal income tax rate 21.00% 34.00% 34.00%
State taxes 12.30% (27.70%)  
Research and development and other tax credits 3.10% 8.50% 1.50%
Valuation allowance (45.50%) (93.20%) (17.30%)
Permanent differences 6.90% 6.40% (3.40%)
Sarepta International C.V. return to provision (0.10%) 62.10%  
Impact of tax reform, net of valuation allowance   5.90%  
Foreign rate differential (0.90%) (0.60%) (14.80%)
Other 3.40% 0.40%  
Effective tax rate 0.20% (4.20%)