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Intangible Assets - Additional Information (Detail) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jul. 31, 2017
Finite Lived Intangible Assets [Line Items]                        
Amortization of in-licensed rights $ 216,000 $ 216,000 $ 217,000 $ 216,000 $ 216,000 $ 780,000 $ 29,000 $ 28,000 $ 865,000 $ 1,053,000 $ 29,000  
Patents [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Amortization of in-licensed rights                 $ 700,000 600,000 600,000  
Initial term of patents                 20 years      
Patents [Member] | Research and Development [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Book value of patent abandoned                 $ 100,000 600,000 300,000  
Impairment loss on patent assets                 3,800,000      
Maximum [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Amortization of in-licensed rights                     100,000  
EXONDYS 51 [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Sales milestone recorded as an in-license right 0       $ 6,600,000       0 $ 6,600,000 $ 1,000,000  
EXONDYS 51 [Member] | Bio Marin [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Sales milestone recorded as an in-license right                       $ 6,600,000
EXONDYS 51 [Member] | University of Western Australia [Member]                        
Finite Lived Intangible Assets [Line Items]                        
Sales milestone recorded as an in-license right $ 1,000,000               $ 1,000,000     $ 1,000,000