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Reconciliation Between Effective Tax Rate and Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
Federal income tax rate 34.00% 34.00% 34.00%
State taxes (27.70%)    
Research and development and other tax credits 8.50% 1.50% 0.30%
Valuation allowance (93.20%) (17.30%) (19.10%)
Permanent differences 6.40% (3.40%) (1.70%)
Sarepta International C.V. return to provision 62.10%    
Impact of tax reform, net of valuation allowance 5.90%    
Foreign rate differential (0.60%) (14.80%) (13.50%)
Other 0.40%    
Effective tax rate (4.20%)