FINANCIAL INFORMATION BY QUARTER (UNAUDITED) (Tables)

12 Months Ended

Dec. 31, 2017

Quarterly Financial Information Disclosure [Abstract]

Financial Information by Quarter

	2017 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenues:
Product, net	$	57,277		$	45,954		$	35,011		$	16,342
Total revenues		57,277			45,954			35,011			16,342
Operating expenses:
Cost of sales (excluding amortization of in-licensed rights)		3,546			3,078			505			224
Research and development		44,441			34,239			58,908			29,119
Selling, general and administrative		32,221			28,176			36,069			26,216
Settlement and license charges		—			25,588			2,839			—
Amortization of in-licensed rights		216			780			29			28
Total cost and operating expenses		80,424			91,861			98,350			55,587
Operating loss		(23,147	)		(45,907	)		(63,339	)		(39,245	)
Other (loss) income:
Interest (expense) income and other, net		(2,693	)		184			184			335
Gain from sale of Priority Review Voucher		—			—			—			125,000
Total other (loss) income		(2,693	)		184			184			125,335
(Loss) income before income tax (benefit) expense		(25,840	)		(45,723	)		(63,155	)		86,090
Income tax (benefit) expense		(1,842	)		2,011			(109	)		2,000
Net (loss) income	$	(23,998	)	$	(47,734	)	$	(63,046	)	$	84,090
Net income (loss) per share:
Basic (loss) earnings per share	$	(0.37	)	$	(0.78	)	$	(1.15	)	$	1.53
Diluted (loss) earnings per share	$	(0.37	)	$	(0.78	)	$	(1.15	)	$	1.50
Weighted average number of shares of common stock used in calculating:
Basic (loss) earnings per share		64,277			61,528			54,976			54,850
Diluted (loss) earnings per share		64,277			61,258			54,976			56,012
	2016 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenues:
Product, net	$	5,421		$	—		$	—		$	—
Total revenues		5,421			—			—			—
Cost and operating expenses:
Cost of sales (excluding amortization of in-licensed rights)		101			—			—			—
Amortization of in-licensed rights		29			—			—			—
Research and development		70,749			34,349			44,348			38,826
Selling, general and administrative		22,937			22,184			17,752			20,876
Total operating expenses		93,816			56,533			62,100			59,702
Operating loss		(88,395	)		(56,533	)		(62,100	)		(59,702	)
Other (loss) income:
Interest expense and other, net		(57	)		(209	)		(201	)		(68	)
Total other loss		(57	)		(209	)		(201	)		(68	)
Net loss	$	(88,452	)	$	(56,742	)	$	(62,301	)	$	(59,770	)
Net loss per share—basic and diluted	$	(1.62	)	$	(1.18	)	$	(1.35	)	$	(1.31	)
Shares used in per share calculations—basic and diluted		54,619			48,254			46,157			45,697