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Stock Based Compensation - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Jun. 30, 2016
Feb. 29, 2016
Oct. 31, 2015
Jun. 30, 2015
Jun. 30, 2013
Nov. 30, 2012
Aug. 31, 2012
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Term of award               10 years      
Share based compensation granted under plan vest period               4 years      
Weighted-average grant date fair value per share of stock-based awards, granted to employees               $ 12.46 $ 14.98 $ 18.59  
Stock-based compensation expense               $ 29,962 $ 32,117 $ 20,345  
Former Chief Executive Officer [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation expense                 8,600    
Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share based compensation granted under plan vest period               4 years      
Stock option grants with performance conditions   300,000     400,000            
Forfeited awards percentage               20.00%      
Stock-based compensation expense               $ 26,320 29,014 18,388  
Stock Options with Performance-based Conditions [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock-based compensation expense               5,000 $ 500 $ 1,200  
Service-Vesting Conditions [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock based compensation expense not yet recognized               28,500      
Stock Options with Service-and Performance-Based Conditions [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Stock based compensation expense not yet recognized               $ 1,900      
Stock Appreciation Rights [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Shares, Granted           100,000 70,000        
Exercise price of SARs           $ 23.85 $ 10.08        
EXONDYS 51 [Member] | Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Performance grants vested percentage                   80.00%  
Performance Grants Vested Immediately [Member] | EXONDYS 51 [Member] | Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Performance grants vested percentage   50.00%                  
Vesting Subject to the Remaining Service Conditions [Member] | EXONDYS 51 [Member] | Stock Options [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Performance grants vested percentage   50.00%                  
2011 Equity Incentive Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common stock remain available for future grant               3,000,000      
Number of shares approved under the plan               13,000,000      
Number of additional shares approved under the plan 1,300,000     1,700,000              
2013 Employee Stock Purchase Plan [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common stock remain available for future grant               300,000      
Number of shares approved under the plan 300,000       300,000            
Term of award               24 months      
Percentage of closing price of common stock               85.00%      
2013 Employee Stock Purchase Plan [Member] | Minimum [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based compensation award, expiration date               Feb. 28, 2018      
2013 Employee Stock Purchase Plan [Member] | Maximum [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Share-based compensation award, expiration date               Aug. 31, 2018      
2014 Employment Commencement Incentive Plan (2014 Plan) [Member]                      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                      
Common stock remain available for future grant               1,100,000      
Number of shares approved under the plan                     600,000
Number of additional shares approved under the plan     1,000,000