FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

12 Months Ended

Dec. 31, 2016

Quarterly Financial Information Disclosure [Abstract]

FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

17. FINANCIAL INFORMATION BY QUARTER (UNAUDITED)

	2016 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenues:
Product, net	$	5,421		$	—		$	—		$	—
Total revenues		5,421			—			—			—
Operating expenses:
Cost of sales		130			—			—			—
Research and development		70,749			34,349			44,348			38,826
Selling, general and administrative		22,937			22,184			17,752			20,876
Total operating expenses		93,816			56,533			62,100			59,702
Operating loss		(88,395	)		(56,533	)		(62,100	)		(59,702	)
Other (loss) income:
Interest expense and other, net		(57	)		(209	)		(201	)		(68	)
Total other loss		(57	)		(209	)		(201	)		(68	)
Net loss	$	(88,452	)	$	(56,742	)	$	(62,301	)	$	(59,770	)
Net loss per share—basic and diluted	$	(1.62	)	$	(1.18	)	$	(1.35	)	$	(1.31	)
Shares used in per share calculations—basic and diluted		54,619			48,254			46,157			45,697
	2015 for Quarter Ended
	December 31			September 30			June 30			March 31
	(in thousands)
Revenue from research contracts and other grants	$	1,253		$	—		$	—		$	—
Operating expenses:
Research and development		41,376			36,673			29,180			39,165
General and administrative		24,329			15,090			12,927			22,697
Total operating expenses		65,705			51,763			42,107			61,862
Operating loss		(64,452	)		(51,763	)		(42,107	)		(61,862	)
Other income (loss):
Interest (expense) income and other, net		(229	)		(176	)		256			303
Total other (loss) income		(229	)		(176	)		256			303
Net loss	$	(64,681	)	$	(51,939	)	$	(41,851	)	$	(61,559	)
Net loss per share—basic and diluted	$	(1.44	)	$	(1.25	)	$	(1.01	)	$	(1.49	)
Shares used in per share calculations—basic and diluted		44,882			41,565			41,357			41,324