-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 RImVB9CzW2YC4wogJ5GOkvBLaXG3+EiRfUYD1Q7cTfwPqqECiQaGWspVYNll+XBv
 m+Zi4azlwju94r2/D+JqyQ==

<SEC-DOCUMENT>0001257957-09-000002.txt : 20090128
<SEC-HEADER>0001257957-09-000002.hdr.sgml : 20090128
<ACCEPTANCE-DATETIME>20090128211133
ACCESSION NUMBER:		0001257957-09-000002
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090126
FILED AS OF DATE:		20090128
DATE AS OF CHANGE:		20090128

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SHREWSBURY STEPHEN B
		CENTRAL INDEX KEY:			0001413821

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14895
		FILM NUMBER:		09552697

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(650) 386-3100

	MAIL ADDRESS:	
		STREET 1:		2400 BAYSHORE PARKWAY
		STREET 2:		SUITE 200
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVI BIOPHARMA INC
		CENTRAL INDEX KEY:			0000873303
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				930797222
		STATE OF INCORPORATION:			OR
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE SW COLUMBIA
		STREET 2:		STE 1105
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97258
		BUSINESS PHONE:		5032270554

	MAIL ADDRESS:	
		STREET 1:		ONE SW COLUMBIA
		STREET 2:		SUITE 1105
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97258

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTIVIRALS INC
		DATE OF NAME CHANGE:	19970123
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-01-26</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000873303</issuerCik>
        <issuerName>AVI BIOPHARMA INC</issuerName>
        <issuerTradingSymbol>AVII</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001413821</rptOwnerCik>
            <rptOwnerName>SHREWSBURY STEPHEN B</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SW COLUMBIA, SUITE 1105</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>PORTLAND</rptOwnerCity>
            <rptOwnerState>OR</rptOwnerState>
            <rptOwnerZipCode>97258</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP/Regulatory Affairs</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>Stephen Bevan Shrewsbury</signatureName>
        <signatureDate>2009-01-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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