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Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Cash flows from operating activities:      
Net loss $ (135,789)us-gaap_NetIncomeLoss $ (111,985)us-gaap_NetIncomeLoss $ (121,287)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to net cash flows used in operating activities:      
Depreciation and amortization 3,690us-gaap_DepreciationDepletionAndAmortization 1,277us-gaap_DepreciationDepletionAndAmortization 1,525us-gaap_DepreciationDepletionAndAmortization
Amortization of premium on available-for-sale securities 2,432us-gaap_AmortizationOfDebtDiscountPremium    
Loss on abandonment of patents and disposal of property and equipment 128us-gaap_GainLossOnDispositionOfAssets1 590us-gaap_GainLossOnDispositionOfAssets1 357us-gaap_GainLossOnDispositionOfAssets1
Stock-based compensation 20,345us-gaap_ShareBasedCompensation 11,127us-gaap_ShareBasedCompensation 3,078us-gaap_ShareBasedCompensation
Loss on change in warrant valuation 2,779us-gaap_FairValueAdjustmentOfWarrants 22,027us-gaap_FairValueAdjustmentOfWarrants 91,938us-gaap_FairValueAdjustmentOfWarrants
Non-cash interest expense 12us-gaap_OtherNoncashExpense    
Changes in operating assets and liabilities, net:      
Net decrease (increase) in accounts receivable 1,114us-gaap_IncreaseDecreaseInAccountsReceivable 1,183us-gaap_IncreaseDecreaseInAccountsReceivable (1,080)us-gaap_IncreaseDecreaseInAccountsReceivable
Net (increase) decrease in other assets (34,013)us-gaap_IncreaseDecreaseInOtherOperatingAssets 1,618us-gaap_IncreaseDecreaseInOtherOperatingAssets (2,507)us-gaap_IncreaseDecreaseInOtherOperatingAssets
Net increase (decrease) in accounts payable, accrued expenses and other liabilities 10,763us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities 9,468us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities (1,718)us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
Net cash used in operating activities (128,539)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (64,695)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (29,694)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities:      
Purchase of restricted investments   (7,897)us-gaap_PaymentsToAcquireRestrictedInvestments  
Purchase of property and equipment (25,444)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (2,370)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (108)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Patent costs (1,381)us-gaap_PaymentsToAcquireIntangibleAssets (1,405)us-gaap_PaymentsToAcquireIntangibleAssets (1,037)us-gaap_PaymentsToAcquireIntangibleAssets
Purchase of available-for-sale securities (274,368)us-gaap_PaymentsToAcquireAvailableForSaleSecurities    
Maturity of available-for-sale securities 134,913us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities    
Release and maturity of restricted investments 7,250us-gaap_ProceedsFromSaleOfRestrictedInvestments    
Net cash used in investing activities (159,030)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (11,672)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations (1,145)us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities:      
Proceeds from exercise of options and warrants and the sale of common stock, net of offering costs 104,249us-gaap_ProceedsFromIssuanceOrSaleOfEquity 145,986us-gaap_ProceedsFromIssuanceOrSaleOfEquity 178,681us-gaap_ProceedsFromIssuanceOrSaleOfEquity
Repayments of long-term debt (94)us-gaap_RepaymentsOfLongTermDebt (89)us-gaap_RepaymentsOfLongTermDebt (85)us-gaap_RepaymentsOfLongTermDebt
Other financing activities, net   (226)us-gaap_ProceedsFromPaymentsForOtherFinancingActivities  
Net cash provided by financing activities 104,155us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 145,671us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 178,596us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
(Decrease) increase in cash and cash equivalents (183,414)us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 69,304us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 147,757us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease
Cash and cash equivalents:      
Beginning of period 256,965us-gaap_CashAndCashEquivalentsAtCarryingValue 187,661us-gaap_CashAndCashEquivalentsAtCarryingValue 39,904us-gaap_CashAndCashEquivalentsAtCarryingValue
End of period 73,551us-gaap_CashAndCashEquivalentsAtCarryingValue 256,965us-gaap_CashAndCashEquivalentsAtCarryingValue 187,661us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash flow information:      
Cash paid during the year for interest 77us-gaap_InterestPaid 144us-gaap_InterestPaid 86us-gaap_InterestPaid
Supplemental schedule of noncash investing activities and financing activities:      
Issuance of common stock in satisfaction of warrants and other liabilities 11,785srpt_IssuanceOfCommonStockAndWarrantsInSatisfactionOfLiabilities 78,214srpt_IssuanceOfCommonStockAndWarrantsInSatisfactionOfLiabilities 32,191srpt_IssuanceOfCommonStockAndWarrantsInSatisfactionOfLiabilities
Issuance of notes payable in relation to the purchase of certain real and personal property located in Andover, Massachusetts 4,613us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction    
Capitalized interest 137us-gaap_InterestPaidCapitalized    
Tenant improvements paid by landlord 153us-gaap_PaymentsForTenantImprovements 6,214us-gaap_PaymentsForTenantImprovements  
Property and equipment included in accrued expenses 277us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1 3,964us-gaap_NoncashOrPartNoncashAcquisitionFixedAssetsAcquired1  
Patent costs included in accrued expenses $ 270us-gaap_NoncashOrPartNoncashAcquisitionIntangibleAssetsAcquired1 $ 195us-gaap_NoncashOrPartNoncashAcquisitionIntangibleAssetsAcquired1