Summary of Accrued Expenses (Detail) (USD $) In Thousands, unless otherwise specified	Jun. 30, 2014	Dec. 31, 2013
Payables And Accruals [Abstract]
Accrued contract manufacturing costs	$ 2,941	$ 1,414
Accrued facility-related costs	556	2,843
Accrued contract research costs	2,240	2,785
Accrued employee compensation costs	3,932	5,048
Accrued professional fees	3,440	1,235
Others	730	1,276
Total accrued expenses	$ 13,839	$ 14,601