Consolidated Statements of Shareholders' Equity (Deficit) (USD $) In Thousands, except Share data	Total USD ($)	Common Stock USD ($)	Additional Paid-In Capital USD ($)	Partnership Units	Deficit Accumulated During The Development Stage USD ($)
BALANCE AT BEGINNING at Jul. 21, 1980	$ 0	$ 0	$ 0		$ 0
BALANCE AT BEGINNING (in shares) at Jul. 21, 1980		0		0
Issuance of partnership units, warrants and common stock, shares		1,379,000		602,000
Issuance of partnership units, warrants and common stock	33,734	0	33,734		0
Compensation expense related to issuance of warrants for common stock and partnership units	537	0	537		0
Exercise of warrants for partnership units and common stock, shares		375,000		7,000
Exercise of warrants for partnership units and common stock	4,152	0	4,152		0
Exercise of options for common stock (in shares)		183,000		0
Exercise of options for common stock	4,209	0	4,209		0
Issuance of common stock for ESPP (in shares)		163,000		0
Issuance of common stock for ESPP	2,417	0	2,417		0
Issuance of common stock and warrants for cash and securities, net of offering costs, shares		14,400,000		0
Issuance of common stock and warrants for cash and securities, net of offering costs	207,322	2	207,320		0
Issuance of common stock and warrants for the acquisition of business interests (in shares)		1,324,000		0
Issuance of common stock and warrants for the acquisition of business interests	25,559	0	25,559		0
Issuance of common stock and warrants to vendors, shares		143,000		0
Issuance of common stock and warrants to vendors	3,297	0	3,297		0
Stock-based compensation, net of cancellations of restricted stock, shares		186,000		0
Stock-based compensation, net of cancellations of restricted stock	18,250	0	18,250		0
Conversion of debt into common stock and partnership units, shares		2,000		2,000
Conversion of debt into common stock and partnership units	88	0	88		0
Issuance of common stock in exchange for partnership units	0	272,000	0	(302,000)	0
Withdrawal of partnership net assets upon conveyance of technology, shares		0		(309,000)
Withdrawal of partnership net assets upon conveyance of technology	(177)	0	(177)		0
Common stock subject to rescission net, shares		(11,000)		0
Common stock subject to rescission, net	(289)	0	(289)		0
Net loss	(275,469)	0	0		(275,469)
BALANCE AT ENDING at Dec. 31, 2009	23,630	2	299,097		(275,469)
BALANCE AT ENDING (in shares) at Dec. 31, 2009		18,416,000		0
Exercise of options for common stock (in shares)	283,605	284,000		0
Exercise of options for common stock	2,012	0	2,012		0
Exercise of warrants for common stock, shares		51,000		0
Exercise of warrants for common stock	549	0	549		0
Stock-based compensation, net of cancellations of restricted stock, shares		(26,000)		0
Stock-based compensation, net of cancellations of restricted stock	3,169	0	3,169		0
Net loss	(32,177)	0	0		(32,177)
BALANCE AT ENDING at Dec. 31, 2010	(2,817)	2	304,827		(307,646)
BALANCE AT ENDING (in shares) at Dec. 31, 2010		18,725,000		0
Exercise of options for common stock (in shares)	25,291	30,000		0
Exercise of options for common stock	166	0	166		0
Exercise of warrants for common stock, shares		35,000		0
Exercise of warrants for common stock	759	0	759		0
Issuance of common stock for cash, net of offering costs, shares		3,834,000		0
Issuance of common stock for cash, net of offering costs	32,098	0	32,098		0
Stock-based compensation, net of cancellations of restricted stock, shares		0		0
Stock-based compensation, net of cancellations of restricted stock	3,129	0	3,129		0
Net loss	(2,318)	0	0		(2,318)
BALANCE AT ENDING at Dec. 31, 2011	31,017	2	340,979		(309,964)
BALANCE AT ENDING (in shares) at Dec. 31, 2011		22,624,000		0
Exercise of options for common stock (in shares)	371,353	372,000		0
Exercise of options for common stock	3,780	0	3,780		0
Exercise of warrants for common stock, shares		1,770,000		0
Exercise of warrants for common stock	52,742	0	52,742		0
Issuance of common stock for cash, net of offering costs, shares		6,934,000		0
Issuance of common stock for cash, net of offering costs	154,349	1	154,348		0
Stock-based compensation, net of cancellations of restricted stock, shares		4,000		0
Stock-based compensation, net of cancellations of restricted stock	3,078	0	3,078		0
Net loss	(121,287)	0	0		(121,287)
BALANCE AT ENDING at Dec. 31, 2012	$ 123,679	$ 3	$ 554,927		$ (431,251)
BALANCE AT ENDING (in shares) at Dec. 31, 2012		31,704,000		0