The cumulative amount of depreciation, depletion and amortization (related to property, plant and equipment, but not including land) that has been recognized in the income statement.

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Gross amount of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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- Definition

Amount, net of accumulated depreciation, depletion and amortization, of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Amounts Included in Property and Equipment (Detail) (USD $)	Dec. 31, 2012	Dec. 31, 2011	Nov. 11, 2011
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 20,105,000	$ 20,030,000
Less accumulated depreciation	(16,708,000)	(15,765,000)
Property and equipment, net	3,397,000	4,265,000
Lab equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	6,890,000	6,920,000
Office equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	1,301,000	1,295,000
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	10,058,000	9,959,000
Building
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 1,856,000	$ 1,856,000	$ 1,856,000