-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 DM3vbSkI6FRuIAH0hTfGMKmsgQPYVm8WmWkLcCdloNI8wcAvIJyiOum4Yu3EQGhj
 KlPseY9l1djVFayXWfEpdw==

<SEC-DOCUMENT>0001144204-10-015920.txt : 20100326
<SEC-HEADER>0001144204-10-015920.hdr.sgml : 20100326
<ACCEPTANCE-DATETIME>20100326153706
ACCESSION NUMBER:		0001144204-10-015920
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100316
FILED AS OF DATE:		20100326
DATE AS OF CHANGE:		20100326

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HAYWOOD GEORGE WEAVER
		CENTRAL INDEX KEY:			0001000514

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14895
		FILM NUMBER:		10707565

	MAIL ADDRESS:	
		STREET 1:		CARE OF CRONIN AND VRIS, LLP
		STREET 2:		380 MADISON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Haywood Cheryl
		CENTRAL INDEX KEY:			0001487750

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14895
		FILM NUMBER:		10707564

	MAIL ADDRESS:	
		STREET 1:		MOOMJIAN, WAITE, WACTLAR & COLEMAN LLP
		STREET 2:		100 JERICHO QUADRANGLE, SUITE 225
		CITY:			JERICHO
		STATE:			NY
		ZIP:			11753

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVI BIOPHARMA INC
		CENTRAL INDEX KEY:			0000873303
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				930797222
		STATE OF INCORPORATION:			OR
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3450 MONTE VILLA PARKWAY
		STREET 2:		SUITE 101
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98021
		BUSINESS PHONE:		425-354-5038

	MAIL ADDRESS:	
		STREET 1:		3450 MONTE VILLA PARKWAY
		STREET 2:		SUITE 101
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98021

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTIVIRALS INC
		DATE OF NAME CHANGE:	19970123
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>v178630_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-03-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000873303</issuerCik>
        <issuerName>AVI BIOPHARMA INC</issuerName>
        <issuerTradingSymbol>AVII</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001000514</rptOwnerCik>
            <rptOwnerName>HAYWOOD GEORGE WEAVER</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>MOOMJIAN, WAITE, WACTLAR &amp; COLEMAN, LLP</rptOwnerStreet1>
            <rptOwnerStreet2>100 JERICHO QUADRANGLE, SUITE 225</rptOwnerStreet2>
            <rptOwnerCity>JERICHO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>11753</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be deemed 10% group member</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001487750</rptOwnerCik>
            <rptOwnerName>Haywood Cheryl</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>MOOMJIAN, WAITE, WACTLAR &amp; COLEMAN, LLP</rptOwnerStreet1>
            <rptOwnerStreet2>100 JERICHO QUADRANGLE, SUITE 225</rptOwnerStreet2>
            <rptOwnerCity>JERICHO</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>11753</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be deemed 10% group member</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7329126</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1000000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.78</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-02-25</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-08-25</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>160000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.45</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2008-06-20</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-12-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1315673</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These securities are owned solely by George W. Haywood, who may be deemed a member of a &quot;group&quot; with Cheryl Haywood, Rockall
 Emerging Markets Master Fund Ltd., Meldrum Asset Management, LLC, Mr. Con Egan and Mr. Conor O'Driscoll for purposes of
 Section 13(d) of the Exchange Act.</footnote>
        <footnote id="F2">These securities are owned solely by Cheryl Haywood.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ George W. Haywood</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Cheryl Haywood</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----