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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001140888-09-000077.txt : 20090602
<SEC-HEADER>0001140888-09-000077.hdr.sgml : 20090602
<ACCEPTANCE-DATETIME>20090602112246
ACCESSION NUMBER:		0001140888-09-000077
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090531
FILED AS OF DATE:		20090602
DATE AS OF CHANGE:		20090602

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVI BIOPHARMA INC
		CENTRAL INDEX KEY:			0000873303
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				930797222
		STATE OF INCORPORATION:			OR
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE SW COLUMBIA
		STREET 2:		STE 1105
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97258
		BUSINESS PHONE:		5032270554

	MAIL ADDRESS:	
		STREET 1:		ONE SW COLUMBIA
		STREET 2:		SUITE 1105
		CITY:			PORTLAND
		STATE:			OR
		ZIP:			97258

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTIVIRALS INC
		DATE OF NAME CHANGE:	19970123

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			EASTBOURNE CAPITAL MANAGEMENT LLC/CA
		CENTRAL INDEX KEY:			0001140888
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14895
		FILM NUMBER:		09867237

	BUSINESS ADDRESS:	
		STREET 1:		1101 FIFTH AVENUE
		STREET 2:		SUITE 370
		CITY:			SAN RAFAEL
		STATE:			CA
		ZIP:			94901
		BUSINESS PHONE:		4154481200

	MAIL ADDRESS:	
		STREET 1:		1101 FIFTH AVENUE
		STREET 2:		SUITE 370
		CITY:			SAN RAFAEL
		STATE:			CA
		ZIP:			94901
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-05-31</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000873303</issuerCik>
        <issuerName>AVI BIOPHARMA INC</issuerName>
        <issuerTradingSymbol>AVII</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001140888</rptOwnerCik>
            <rptOwnerName>EASTBOURNE CAPITAL MANAGEMENT LLC/CA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1101 FIFTH AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 370</rptOwnerStreet2>
            <rptOwnerCity>SAN RAFAEL</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94901</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14224138</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Eastbourne Capital Management, L.L.C. (&quot;Eastbourne&quot;) is the general partner or manager and investment adviser of investment funds that hold these securities directly on behalf of those funds' investors.  Richard Jon Barry is Eastbourne's manager and controlling person.  Eastbourne and Mr. Barry hold these securities indirectly in their capacity as investment adviser and control person, respectively.  Eastbourne is filing this Form 3 on behalf of itself and Mr. Barry, jointly, but not as members of a group, and each of them disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended.  In addition, each of them disclaims beneficial ownership of such securities, except to the extent of its pecuniary interest therein</footnote>
        <footnote id="F2">Eastbourne Capital Management, L.L.C. is the beneficial owner of more than 10 percent of the outstanding common stock of Avi BioPharma, Inc.  Under a Letter Agreement Regarding Board of Director Representation dated as of January 30, 2009, between Eastbourne Capital Management, L.L.C. and Avi BioPharma, Inc., Avi BioPharma, Inc. agreed to take all necessary actions to have one designee of Eastbourne Capital Management, L.L.C. nominated to Avi BioPharma, Inc.'s Board of Directors. Pursuant to this agreement, Dr. Kathleen Behrens currently serves on the Board of Directors of Avi BioPharma, Inc.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Eric Sippel</signatureName>
        <signatureDate>2009-06-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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