Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024		Mar. 31, 2023
Cash flows from operating activities:
Net income (loss)	$ 36,119		$ (516,755)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	8,744		11,305
Reduction in the carrying amounts of the right of use assets	3,952		3,218
Stock-based compensation	40,692		41,250
Accretion of investment discount, net	(12,401)		(8,651)
Loss on debt extinguishment	0		387,329
Non-cash change in the fair value of contingent consideration	10,100		0
Other	329		1,964
Changes in operating assets and liabilities, net:
Net decrease (increase) in accounts receivable, net	21,521		(9,208)
Net increase in inventory	(60,512)		(306)
Net increase in manufacturing-related deposits and prepaids	(145,046)		(7,479)
Net increase in other assets	(2,315)		(22,517)
Net decrease in deferred revenue	(50,416)		(22,005)
Net decrease in accounts payable, accrued expenses, lease liabilities and other liabilities	(92,843)		(67,541)
Net cash used in operating activities	(242,076)		(209,396)
Cash flows from investing activities:
Purchase of property and equipment	(32,444)		(9,485)
Purchase of available-for-sale securities	(216,450)		(426,763)
Maturity and sales of available-for-sale securities	477,690		448,834
Purchase of intangible assets	(10,000)		(94)
Net cash provided by investing activities	218,796		12,492
Cash flows from financing activities:
Proceeds from exercise of stock options and purchase of stock under the Employee Stock Purchase Program	22,140		28,037
Partial settlement of capped call share options for 2024 Notes	0		80,645
Debt conversion costs for 2024 Notes	0		(6,887)
Net cash provided by financing activities	22,140		101,795
Decrease in cash, cash equivalents and restricted cash	(1,140)		(95,109)
Cash, cash equivalents and restricted cash:
Beginning of period	444,009		985,801
End of period	442,869		890,692
Reconciliation of cash, cash equivalents and restricted cash:
Total cash, cash equivalents and restricted cash	442,869		890,692
Cash and cash equivalents	427,290		871,668
Restricted cash in other assets	15,579	[1]	19,024
Supplemental disclosure of cash flow information:
Cash paid during the period for income taxes	909		535
Cash paid during the period for interest	7,188		7,023
Supplemental schedule of non-cash investing activities and financing activities:
Intangible assets and property and equipment included in accounts payable and accrued expenses	22,929		11,136
Lease liabilities arising from obtaining right of use assets	275		280
Capitalized stock-based compensation and depreciation as inventory	6,333
Common stock issued for exchange of 2024 Notes	$ 0		$ 693,377

[1] The Company had approximately $15.6 million in restricted cash included in other non-current assets on the Company’s unaudited condensed consolidated balance sheets as of both March 31, 2024 and December 31, 2023. Restricted cash for both periods relates to (i) letters of credit established under the Company’s various property leases that serve as security for potential future default of lease payments, (ii) a letter of credit established under a certain commercial supply agreement and (iii) collateralized cash for the Company’s credit cards. The restricted cash is unavailable for withdrawal or use for general obligations