Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Cumulative Effect of Accounting Change [Member]	Common Stock [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] Cumulative Effect of Accounting Change [Member]	Accumulated Other Comprehensive Gain (Loss) [Member]	Accumulated Deficit [Member]	Accumulated Deficit [Member] Cumulative Effect of Accounting Change [Member]
Balance at Dec. 31, 2020	$ 761,759	$ (96,792)	$ 8	$ 3,609,877	$ (156,953)	$ 3	$ (2,848,129)	$ 60,161
Balance (in shares) at Dec. 31, 2020			79,374
Exercise of options for common stock	12,963			12,963
Exercise of options for common stock, shares			283
Vest of restricted stock units/awards			277
Shares withheld for taxes	(1,432)			(1,432)
Shares withheld for taxes, shares			(18)
Issuance of common stock for cash, net of offering costs	548,532		$ 1	548,531
Issuance of common stock for cash, net of offering costs, shares			7,099
Issuance of common stock under employee stock purchase plan	7,839			7,839
Issuance of common stock under employee stock purchase plan, shares			112
Stock-based compensation	113,943			113,943
Purchase of capped call share options for 2027 Notes	0
Partial settlement of capped call share options for 2024 Notes	0
Unrealized losses from available-for-sale securities, net of tax	(23)					(23)
Net loss	(418,780)						(418,780)
Balance at Dec. 31, 2021	928,009		$ 9	4,134,768		(20)	(3,206,748)
Balance (in shares) at Dec. 31, 2021			87,127
Exercise of options for common stock	22,573			22,573
Exercise of options for common stock, shares			318
Vest of restricted stock units/awards			389
Issuance of common stock under employee stock purchase plan	7,470			7,470
Issuance of common stock under employee stock purchase plan, shares			116
Stock-based compensation	233,018			233,018
Purchase of capped call share options for 2027 Notes	(127,305)			(127,305)
Partial settlement of capped call share options for 2024 Notes	26,317			26,317
Unrealized losses from available-for-sale securities, net of tax	(1,644)					(1,644)
Net loss	(703,488)						(703,488)
Balance at Dec. 31, 2022	384,950		$ 9	4,296,841		(1,664)	(3,910,236)
Balance (in shares) at Dec. 31, 2022			87,950
Exercise of options for common stock	$ 40,485			40,485
Exercise of options for common stock, shares	528,909		528
Vest of restricted stock units/awards			645
Issuance of common stock for exchange of 2024 Notes, shares			4,456
Issuance of common stock for exchange of 2024 Notes, value	$ 693,377			693,377
Issuance of common stock under employee stock purchase plan	10,761			10,761
Issuance of common stock under employee stock purchase plan, shares			153
Stock-based compensation	182,514			182,514
Purchase of capped call share options for 2027 Notes	0
Partial settlement of capped call share options for 2024 Notes	80,645			80,645
Unrealized losses from available-for-sale securities, net of tax	2,582					2,582
Net loss	(535,977)						(535,977)
Balance at Dec. 31, 2023	$ 859,337		$ 9	$ 5,304,623		$ 918	$ (4,446,213)
Balance (in shares) at Dec. 31, 2023			93,732