Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues:
Products, net	$ 1,144,876	$ 843,769	$ 612,401
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Collaboration and other	$ 98,460	$ 89,244	$ 89,486
Total revenues	1,243,336	933,013	701,887
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	150,343	139,989	97,049
Research and development	877,387	877,090	771,182
Selling, general and administrative	481,871	451,421	282,660
Settlement and license charges	0	0	10,000
Amortization of in-licensed rights	1,559	714	706
Total cost and expenses	1,511,160	1,469,214	1,161,597
Operating loss	(267,824)	(536,201)	(459,710)
Other (loss) income, net:
Loss on debt extinguishment	(387,329)	(125,441)	0
Gain from sale of Priority Review Voucher	102,000	0	102,000
Other income (expense), net	33,055	(28,321)	(61,238)
Total other (loss) income, net	(252,274)	(153,762)	40,762
Total	(520,098)	(689,963)	(418,948)
Income tax expense (benefit)	15,879	13,525	(168)
Net loss	(535,977)	(703,488)	(418,780)
Other comprehensive income (loss):
Unrealized gains (losses) on investments, net of tax	2,582	(1,644)	(23)
Total other comprehensive income (loss)	2,582	(1,644)	(23)
Comprehensive loss	$ (533,395)	$ (705,132)	$ (418,803)
Net loss per share - basic	$ (5.8)	$ (8.03)	$ (5.15)
Net loss per share - diluted	$ (5.8)	$ (8.03)	$ (5.15)
Weighted average number of shares of common stock used in computing basic net loss per share	92,398	87,559	81,262
Weighted average number of shares of common stock used in computing diluted net loss per share	92,398	87,559	81,262