Stock Based Compensation - Summary of Stock Awards Granted (Detail) - $ / shares	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023		Sep. 30, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants, Stock options	50,875	127,100	1,135,799		1,626,220
Weighted Average Grant Date Fair Value, Stock options	$ 66.53	$ 59.84	$ 72.23		$ 47.54
Grants, Restricted stock units	27,539	65,657	1,137,202	[1]	925,167	[2]
Weighted Average Grant Date Fair Value, Restricted stock units	$ 118.05	$ 105.28	$ 153.02		$ 80.66
Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Grants, Stock options			502,225		38,500

[1] Included in restricted stock units (“RSUs”) for the nine months ended September 30, 2023 are 502,225 shares with performance conditions (the “March 2023 PSUs”) which are related to regulatory approval of certain of the Company's product candidates and achievement of a certain financial performance target.

[2] Included in the RSUs for the nine months ended September 30, 2022 are 38,500 shares of PSUs (the “March 2022 PSUs”) with performance conditions related to regulatory approval of the Company's product candidates.