License and Collaboration Agreements - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Product revenues, net	$ 309,322	$ 207,774	$ 779,805	$ 607,836
Cost of sales (excluding amortization of in-licensed rights)	37,026	39,952	106,167	109,190
Development Milestone and Upfront Fee Recognized as Research and Development Expense	3,800	5,500	11,900	14,300
Collaborative Arrangement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Payment for option exercise			221,300
Research, option and milestone expense	3,800	6,000	3,800	6,000
Collaborative Arrangement | Maximum [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contingent research milestone payments			36,100
Development Milestone and Settlement Upfront Fee Recognized as Research and Development Expense	3,200,000		3,200,000
Collaborative Arrangement | Research and Development Expense [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Up-front and development milestone expenses		5,000	7,500	5,000
Collaborative Arrangement | Roche Holding A.G. [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Product revenues, net	22,500	66,800	22,500	66,800
Deferred Revenue	507,500		507,500
Deferred Revenue, Current	22,500		22,500
Deferred Revenue Separate Material Options Right	485,000		485,000		$ 485,000
Research and development expense	34,900	$ 22,000	83,400	$ 66,100
Collaboration Receivable	35,400		35,400
Nationwide License Agreement [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Licensed Right Intangible Asset	2,000		2,000
Carrying value	2,000		2,000
Cost of sales (excluding amortization of in-licensed rights)	2,100		2,100
Nationwide License Agreement [Member] | Nationwide Childrens Hospital [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Sales milestone payment recorded as an in-license right	9,800		9,800
Carrying value	$ 10,000		$ 10,000