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Stock Based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended			6 Months Ended
	Jun. 30, 2017	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expense		$ 47,377		$ 102,892	$ 88,627	$ 132,090
Stock-based compensation expenses		$ 47,400		$ 102,900
Grants, Stock options		54,575		207,583	1,084,924	1,499,120
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award					550,110 options relating to the Unvested Tranche met the conditions for vesting as the average closing price of the Company's common stock exceeded $128.65 during 20 consecutive trading days in March 2023 and the compound annual growth rate of the Company's common stock exceeded that of the Nasdaq Biotech Index by greater than 5%
Chief Executive Officer
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expenses					$ 12,800
Grants, Stock options	3,300,000
Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Compound annual growth rate					5.00%
Unvested Tranche Member
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expenses					$ 88,600	$ 132,100
Incremental compensation cost					$ 600
Vesting, Stock options					550,110
Average closing price			$ 128.65
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award			550,110 options relating to the Unvested Tranche met the conditions for vesting as the average closing price of the Company's common stock exceeded $128.65 during 20 consecutive trading days in March 2023 and the compound annual growth rate of the Company's common stock exceeded that of the Nasdaq Biotech Index by greater than 5%.
Unvested Tranche Member \| Chief Executive Officer
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock-based compensation expenses		$ 4,400