Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues:
Products, net	$ 238,988	$ 211,237	$ 470,483	$ 400,062
Type of Revenue [Extensible List]			us-gaap:ProductMember	us-gaap:ProductMember
Collaboration	22,250	22,250	$ 44,255	$ 44,255
Total revenues	261,238	233,487	514,738	444,317
Cost and expenses:
Cost of sales (excluding amortization of in-licensed rights)	34,124	37,795	69,141	69,238
Research and development	241,890	252,329	487,569	446,579
Selling, general and administrative	118,564	154,316	229,278	226,156
Amortization of in-licensed rights	179	179	357	357
Total cost and expenses	394,757	444,619	786,345	742,330
Operating loss	(133,519)	(211,132)	(271,607)	(298,013)
Other loss, net:
Gain from sale of Priority Review Voucher	102,000	0	102,000	0
Loss on debt extinguishment	0	0	(387,329)	0
Other income (expense), net	16,934	(16,961)	29,641	(34,226)
Total other (loss), net	118,934	(16,961)	(255,688)	(34,226)
Loss before income tax expense (benefit)	(14,585)	(228,093)	(527,295)	(332,239)
Income tax expense (benefit)	9,355	3,388	13,400	4,267
Net loss	(23,940)	(231,481)	(540,695)	(336,506)
Other comprehensive income (loss):
Unrealized gains (losses) on investments, net of tax	(636)	(2,179)	609	(2,465)
Total other comprehensive income (loss)	(636)	(2,179)	609	(2,465)
Comprehensive loss	$ (24,576)	$ (233,660)	$ (540,086)	$ (338,971)
Net loss per share - basic	$ (0.27)	$ (2.65)	$ (6.11)	$ (3.85)
Net loss per share - diluted	$ (0.27)	$ (2.65)	$ (6.11)	$ (3.85)
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	88,743	87,511	88,466	87,383
Weighted average number of shares of common stock used in computing basic and diluted net loss per share	88,743	87,511	88,466	87,383