As of 
June 30,
2023

As of 
December 31,
2022

(in thousands)

Accrued contract manufacturing costs

$

82,734

$

202,173

Product revenue related reserves

80,424

68,784

Accrued employee compensation costs

44,906

65,946

Accrued clinical and pre-clinical costs

39,786

28,884

Accrued income taxes

20,815

12,521

Accrued professional fees

19,984

12,061

Accrued milestone and license costs

11,200

7,702

Accrued royalties

8,583

8,636

Accrued fixed assets

6,027

984

Accrued research costs

2,627

1,629

Other

9,791

9,676

Total accrued expenses

$

326,877

$

418,996